PMID- 25961789
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 May 11
TI  - Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling.
PG  - 10071
LID - 10.1038/srep10071 [doi]
LID - 10071
AB  - Cancer neovascularization plays an essential role in the metastasis of larynx 
      carcinoma (LC). However, the underlying molecular mechanisms are not completely 
      understood. Recently, we reported that placental growth factor (PLGF) regulates 
      expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling 
      pathway in LC. Here, we show that MMP9 upregulated in LC, and appeared to be 
      mainly produced by M2 macrophages (tumor-associated macrophages (TAM)). In a 
      transwell co-culture system, PLGF secreted by LC cells triggered macrophage 
      polarization to a TAM subtype that releases MMP9. Moreover, MMP9 was found to be 
      activated in the PLGF-polarized TAM via transforming growth factor beta (TGFbeta) 
      receptor signaling activation. Furthermore, PLGF in LC cells induced macrophage 
      polarization in vivo, and significantly promoted the growth of LC. Thus, together 
      with our previous work, our study highlights a pivotal role of cross-talk between 
      TAM and LC in regulating the metastasis of LC.
FAU - Zhou, Xu
AU  - Zhou X
AD  - 1] Otorhinolaryngology Department, Zhongshan Hospital, Fu Dan University, 180 
      Fenglin Road, Shanghai 200032, China [2] State Key Laboratory of Molecular 
      Engineering of Polymers (Fudan University), 220 Handan Road, Shanghai 200433, 
      China.
FAU - Qi, Ying
AU  - Qi Y
AD  - Otorhinolaryngology Department, Zhongshan Hospital, Fu Dan University, 180 
      Fenglin Road, Shanghai 200032, China.
LA  - eng
PT  - Journal Article
DEP - 20150511
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PGF protein, human)
RN  - 0 (Pgf protein, mouse)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.17 (Mmp3 protein, mouse)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - *MAP Kinase Signaling System
MH  - Macrophages/*metabolism/pathology
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Mice
MH  - Neoplasm Proteins/*metabolism
MH  - Placenta Growth Factor
MH  - Pregnancy Proteins/*metabolism
MH  - Transforming Growth Factor beta/metabolism
PMC - PMC4650800
EDAT- 2015/05/12 06:00
MHDA- 2016/03/05 06:00
PMCR- 2015/05/11
CRDT- 2015/05/12 06:00
PHST- 2014/11/17 00:00 [received]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2015/05/11 00:00 [pmc-release]
AID - srep10071 [pii]
AID - 10.1038/srep10071 [doi]
PST - epublish
SO  - Sci Rep. 2015 May 11;5:10071. doi: 10.1038/srep10071.