PMID- 25962150
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 5
DP  - 2015
TI  - Correlation between Serum Level of Monocyte Chemoattractant Protein-1 and 
      Postoperative Recurrence of Spinal Tuberculosis in the Chinese Han Population.
PG  - e0125756
LID - 10.1371/journal.pone.0125756 [doi]
LID - e0125756
AB  - OBJECTIVE: To correlate serum level of monocyte chemoattractant protein-1 (MCP-1) 
      with postoperative recurrence of spinal tuberculosis in the Chinese Han 
      population. METHODS: Patients of Han nationality with newly diagnosed spinal 
      tuberculosis were consecutively included in this study. At different time points 
      postoperatively, serum level of MCP-1 was determined using an enzyme linked 
      immunosorbent assay. Recurrence of spinal tuberculosis after surgery and during 
      the follow-up period was recorded. The correlation between serum MCP-1 level and 
      recurrence of spinal tuberculosis was analyzed. RESULTS: A total of 169 patients 
      with spinal tuberculosis were included in the study and followed up for an 
      average of 2.2 +/- 1.3 years (range, 1-5 years). Of these patients, 11 had 
      postoperative recurrence of spinal tuberculosis. The patients' serum level of 
      MCP-1 increased significantly after postoperative recurrence of spinal 
      tuberculosis. Once the symptoms of recurrence were cured, the serum level of 
      MCP-1 decreased significantly and it did not differ from patients without disease 
      recurrence. CONCLUSION: Postoperative recurrence of spinal tuberculosis is likely 
      to increase the serum level of MCP-1.
FAU - He, Dan
AU  - He D
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, People's 
      Republic of China.
FAU - Zhang, Xiaolu
AU  - Zhang X
AD  - DepartmentofOrthopedics, The second affiliated Hospital, Fujian Medical 
      University, Quanzhou, People's Republic of China.
FAU - Gao, Qile
AU  - Gao Q
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
FAU - Huang, Rongfu
AU  - Huang R
AD  - Clinical Laboratory, The second affiliated Hospital, Fujian Medical University, 
      Quanzhou, People's Republic of China.
FAU - Deng, Zhansheng
AU  - Deng Z
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
FAU - Guo, Chaofeng
AU  - Guo C
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
FAU - Guo, Qiang
AU  - Guo Q
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
FAU - Huang, Jia
AU  - Huang J
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
FAU - Zhang, Hongqi
AU  - Zhang H
AD  - Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, 
      Central South University, Changsha, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150511
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Recurrence
MH  - Tomography, X-Ray Computed
MH  - Tuberculosis, Spinal/*blood/diagnosis/*microbiology/surgery
MH  - Young Adult
PMC - PMC4427401
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/05/12 06:00
MHDA- 2016/02/04 06:00
PMCR- 2015/05/11
CRDT- 2015/05/12 06:00
PHST- 2014/11/21 00:00 [received]
PHST- 2015/03/26 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
PHST- 2015/05/11 00:00 [pmc-release]
AID - PONE-D-14-52480 [pii]
AID - 10.1371/journal.pone.0125756 [doi]
PST - epublish
SO  - PLoS One. 2015 May 11;10(5):e0125756. doi: 10.1371/journal.pone.0125756. 
      eCollection 2015.