PMID- 25962361
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20161125
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 12
IP  - 2
DP  - 2015 Aug
TI  - Effects of dietary trans-9 octadecenoic acid, trans-11 vaccenic acid and cis-9, 
      trans-11 conjugated linoleic acid in mice.
PG  - 3200-6
LID - 10.3892/mmr.2015.3767 [doi]
AB  - The aim of the present study was to investigate the effects of dietary trans 
      fatty acids in mice. Following the administration of a 0.5/100 g diet of trans-9 
      octadecenoic acid (EA), trans-11 vaccenic acid (TVA) or cis-9, trans-11 
      conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of 
      the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually 
      decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and 
      triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA 
      decreased villus length (P<0.05). The TVA group exhibited the lowest levels of 
      low-density lipoprotein and tumor necrosis factor-alpha (P<0.05). Taken together, EA, 
      TVA and CLA affected the physiological conditions of mice differently. The 
      potential effects of three well-known fatty acids, including trans-9 octadecenoic 
      acid (EA), trans-11 vaccenic acid (TVA) and cis-9, trans-11 conjugated linoleic 
      acid (CLA), in animals or humans remain to be elucidated. Therefore, in the 
      present study, 32 animals were randomly divided into four groups and administered 
      a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the 
      body weights and the weights of the liver, testis and mediastinal adipose tissue 
      (MAT) of the animals gradually decreased (P<0.05). Blood was collected 
      individually via the external jugular veins and the EA group exhibited the lowest 
      levels of magnesium and triglycerides (P<0.05). CLA increased villus length 
      (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group 
      exhibited the lowest levels of low-density lipoprotein and tumor necrosis 
      factor-alpha (P<0.05). Taken together, EA, TVA and CLA affected the physiological 
      conditions of mice differently and these may further our understanding of the 
      various effects of these fatty acids on animals and humans.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Animal Nutrition and Feed Science, College of Animal Science and 
      Technology, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
FAU - Lim, Ji-Na
AU  - Lim JN
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Lee, Jae-Sung
AU  - Lee JS
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Lee, Sang-Bum
AU  - Lee SB
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Hwang, Jin-Hee
AU  - Hwang JH
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Jung, U-Suk
AU  - Jung US
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Kim, Min-Jeong
AU  - Kim MJ
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Hwang, Dae-Youn
AU  - Hwang DY
AD  - Department of Biomaterials Science, College of Natural Resources and Life 
      Science, Pusan National University, Miryang, Gyeongnam 627‑706, Republic of 
      Korea.
FAU - Lee, Sang-Rak
AU  - Lee SR
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
FAU - Roh, Sang-Gun
AU  - Roh SG
AD  - Lab of Animal Physiology, Graduate School of Agriculture Science, Tohoku 
      University, Sendai, Miyagi 988‑8555, Japan.
FAU - Lee, Hong-Gu
AU  - Lee HG
AD  - Department of Animal Science and Technology, College of Animal Bioscience and 
      Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150508
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Dietary Fats)
RN  - 0 (Linoleic Acids, Conjugated)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Oleic Acids)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (cis-9, trans-11-conjugated linoleic acid)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - GQ72OGU4EV (11-octadecenoic acid)
SB  - IM
MH  - Adipose Tissue/*drug effects/metabolism
MH  - Animals
MH  - Body Weight/*drug effects
MH  - Dietary Fats/*administration & dosage
MH  - Linoleic Acids, Conjugated/*administration & dosage
MH  - Lipoproteins, LDL/blood
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Mediastinum
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Oleic Acid/*administration & dosage
MH  - Oleic Acids/*administration & dosage
MH  - Testis/drug effects/metabolism
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2015/05/13 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/05/13 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2015/04/10 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.3892/mmr.2015.3767 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Aug;12(2):3200-6. doi: 10.3892/mmr.2015.3767. Epub 2015 May 8.