PMID- 25962831
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20161230
IS  - 1939-3806 (Electronic)
IS  - 1939-3806 (Linking)
VI  - 9
IP  - 1
DP  - 2016 Jan
TI  - Altered Medial Frontal and Superior Temporal Response to Implicit Processing of 
      Emotions in Autism.
PG  - 55-66
LID - 10.1002/aur.1496 [doi]
AB  - Interpreting emotional expressions appropriately poses a challenge for 
      individuals with autism spectrum disorder (ASD). In particular, difficulties with 
      emotional processing in ASD are more pronounced in contexts where emotional 
      expressions are subtle, automatic, and reflexive-that is, implicit. In contrast, 
      explicit emotional processing, which requires the cognitive evaluation of an 
      emotional experience, appears to be relatively intact in individuals with ASD. In 
      the present study, we examined the brain activation and functional connectivity 
      differences underlying explicit and implicit emotional processing in age- and 
      IQ-matched adults with (n = 17) and without (n = 15) ASD. Results indicated: (1) 
      significantly reduced levels of brain activation in participants with ASD in 
      medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit 
      emotion processing; (2) significantly weaker functional connectivity in the ASD 
      group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, 
      and fusiform gyrus; (3) No group difference in performance accuracy or reaction 
      time; and (4) Significant positive relationship between empathizing ability and 
      STG activity in ASD but not in typically developing participants. These findings 
      suggest that the neural mechanisms underlying implicit, but not explicit, emotion 
      processing may be altered at multiple levels in individuals with ASD.
CI  - (c) 2015 International Society for Autism Research, Wiley Periodicals, Inc.
FAU - Kana, Rajesh K
AU  - Kana RK
AD  - Department of Psychology, University of Alabama at Birmingham, USA.
FAU - Patriquin, Michelle A
AU  - Patriquin MA
AD  - Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 
      USA.
FAU - Black, Briley S
AU  - Black BS
AD  - Department of Psychology, University of Alabama at Birmingham, USA.
FAU - Channell, Marie M
AU  - Channell MM
AD  - MIND Institute, University of California Davis, USA.
FAU - Wicker, Bruno
AU  - Wicker B
AD  - Institut de Neurosciences de la Timone, CNRS & Aix-Marseille Universite, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150511
PL  - United States
TA  - Autism Res
JT  - Autism research : official journal of the International Society for Autism 
      Research
JID - 101461858
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autism Spectrum Disorder/*physiopathology
MH  - Brain/*physiopathology
MH  - Brain Mapping/*methods
MH  - Emotions/*physiology
MH  - Facial Expression
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Reaction Time
MH  - Reproducibility of Results
MH  - Social Perception
MH  - Young Adult
OTO - NOTNLM
OT  - autism
OT  - explicit emotion
OT  - fMRI
OT  - functional connectivity
OT  - implicit emotion
EDAT- 2015/05/13 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/05/13 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/04/04 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.1002/aur.1496 [doi]
PST - ppublish
SO  - Autism Res. 2016 Jan;9(1):55-66. doi: 10.1002/aur.1496. Epub 2015 May 11.