PMID- 25963531 OWN - NLM STAT- MEDLINE DCOM- 20160304 LR - 20150606 IS - 1532-2785 (Electronic) IS - 0143-4179 (Linking) VI - 51 DP - 2015 Jun TI - Chronic stress associated with hypercaloric diet changes the hippocampal BDNF levels in male Wistar rats. PG - 75-81 LID - S0143-4179(15)00012-8 [pii] LID - 10.1016/j.npep.2015.01.002 [doi] AB - Chronic stress, whether associated with obesity or not, leads to different neuroendocrine and psychological changes. Obesity or being overweight has become one of the most serious worldwide public health problems. Additionally, it is related to a substantial increase in daily energy intake, which results in substituting nutritionally adequate meals for snacks. This metabolic disorder can lead to morbidity, mortality, and reduced quality of life. On the other hand, brain-derived neurotrophic factor (BDNF) is widely expressed in all brain regions, particularly in the hypothalamus, where it has important effects on neuroprotection, synaptic plasticity, mammalian food intake-behavior, and energy metabolism. BDNF is involved in many activities modulated by the hypothalamic-pituitary-adrenal (HPA) axis. Therefore, this study aims to evaluate the effect of obesity associated with chronic stress on the BDNF central levels of rats. Obesity was controlled by analyzing the animals' caloric intake and changes in body weight. As a stress parameter, we analyzed the relative adrenal gland weight. We found that exposure to chronic restraint stress during 12 weeks increases the adrenal gland weight, decreases the BDNF levels in the hippocampus and is associated with a decrease in the calorie and sucrose intake, characterizing anhedonia. These effects can be related stress, a phenomenon that induces depression-like behavior. On the other hand, the rats that received the hypercaloric diet had an increase in calorie intake and became obese, which was associated with a decrease in hypothalamus BDNF levels. CI - Copyright (c) 2015. Published by Elsevier Ltd. FAU - Macedo, I C AU - Macedo IC AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Graduate Program in Biological Sciences - Physiology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil. FAU - Rozisky, J R AU - Rozisky JR AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Oliveira, C AU - Oliveira C AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Oliveira, C M AU - Oliveira CM AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Laste, G AU - Laste G AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Nonose, Y AU - Nonose Y AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil. FAU - Santos, V S AU - Santos VS AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil. FAU - Marques, P R AU - Marques PR AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Ribeiro, M F M AU - Ribeiro MF AD - Graduate Program in Biological Sciences - Physiology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Neuro-Humoral Interaction Laboratory, Department of Physiology - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90050-170, Brazil. FAU - Caumo, W AU - Caumo W AD - Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. FAU - Torres, I L S AU - Torres IL AD - Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Graduate Program in Biological Sciences - Physiology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. Electronic address: 87605@ufrgs.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150212 PL - Netherlands TA - Neuropeptides JT - Neuropeptides JID - 8103156 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Anhedonia MH - Animals MH - Behavior, Animal/physiology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - *Diet MH - Energy Intake/*physiology MH - Hippocampus/*metabolism MH - Hypothalamo-Hypophyseal System/metabolism MH - Male MH - Obesity/metabolism MH - Pituitary-Adrenal System/metabolism MH - Rats MH - Rats, Wistar MH - Stress, Physiological/*physiology MH - Stress, Psychological/*metabolism OTO - NOTNLM OT - Anhedonia OT - BDNF OT - Chronic stress OT - Hippocampus OT - Hypothalamus OT - Obesity EDAT- 2015/05/13 06:00 MHDA- 2016/03/05 06:00 CRDT- 2015/05/13 06:00 PHST- 2014/05/15 00:00 [received] PHST- 2014/11/21 00:00 [revised] PHST- 2015/01/21 00:00 [accepted] PHST- 2015/05/13 06:00 [entrez] PHST- 2015/05/13 06:00 [pubmed] PHST- 2016/03/05 06:00 [medline] AID - S0143-4179(15)00012-8 [pii] AID - 10.1016/j.npep.2015.01.002 [doi] PST - ppublish SO - Neuropeptides. 2015 Jun;51:75-81. doi: 10.1016/j.npep.2015.01.002. Epub 2015 Feb 12.