PMID- 25964036
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20150512
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 45
IP  - 1
DP  - 2015 Mar
TI  - Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with 
      and without type 2 diabetes.
PG  - 30-6
AB  - AIMS: The onset of insulin resistance is an important metabolic event in the 
      development of type 2 diabetes. For patients with type 2 diabetes, we recently 
      showed that peripheral insulin sensitivity was increased during hyperbaric oxygen 
      treatment (HBOT). This study aims to investigate whether this occurs in a 
      non-patient population with and without type 2 diabetes, along with the mechanism 
      of this effect. METHODS: Overweight and obese male participants were recruited 
      from the community, 11 without and eight with type 2 diabetes. Insulin 
      sensitivity was measured by the glucose infusion rate (GIR) during a 
      hyperinsulinaemic euglycaemic clamp (80 mU.m(-)(2).min(-)(1)) at baseline and during the 
      third HBOT session. Monocyte chemo-attractant protein-1 (MCP-1), tumour necrosis 
      factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were measured in fasting serum and 
      adipose tissue samples taken for their gene expression at baseline and 
      immediately following four HBOT sessions. Additional fasting serum samples were 
      collected during the first HBOT at 0, 60 and 120 minutes, and 24-hours after the 
      last HBOT. RESULTS: In response to HBOT, GIR was increased by 29+/-32% in those 
      without (n=10, P=0.01), and by 57+/-66% in those with type 2 diabetes (n=7, 
      P=0.04). This increase was maintained for 30 minutes post HBOT. Reduced MCP-1 and 
      TNF-alpha were observed after HBOT, whereas IL-6 was increased only in individuals 
      without diabetes and this correlated with the increase in insulin sensitivity 
      (r(2)=0.72, P=0.004). CONCLUSIONS: Peripheral insulin sensitivity was increased 
      following HBOT in overweight or obese males with and without type 2 diabetes; 
      this increase was maintained for at least 30 minutes post HBOT. Changes in 
      inflammatory cytokines may partly explain this effect.
FAU - Wilkinson, David
AU  - Wilkinson D
AD  - Discipline of Medicine, The University of Adelaide, Hyperbaric Medicine Unit, 
      Royal Adelaide Hospital North Terrace, Adelaide, South Australia 5000, Australia, 
      Phone: +61-(0)8-8222-5116, Fax: +61-(0)8-8232-4207, E-mail: 
      david.wilkinson@health.sa.gov.au.
FAU - Nolting, Mirjam
AU  - Nolting M
AD  - Hyperbaric Medicine Unit, Royal Adelaide Hospital, Adelaide, Australia.
FAU - Mahadi, Mohd Kaisan
AU  - Mahadi MK
AD  - Discipline of Medicine, The University of Adelaide, Adelaide, Australia.
FAU - Chapman, Ian
AU  - Chapman I
AD  - Discipline of Medicine, The University of Adelaide, Adelaide, Australia.
FAU - Heilbronn, Leonie
AU  - Heilbronn L
AD  - Discipline of Medicine, The University of Adelaide, Adelaide, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-1 Type I)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Blood Glucose/analysis
MH  - Chemokine CCL2/analysis
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Fasting/blood
MH  - Glucose/administration & dosage
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Interleukin-6/analysis
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/metabolism
MH  - Overweight/blood/*metabolism
MH  - Receptors, Interleukin-1 Type I/antagonists & inhibitors
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/analysis
OTO - NOTNLM
OT  - Endocrinology
OT  - diabetes
OT  - hyperbaric oxygen
OT  - hyperbaric research
OT  - inflammation
OT  - metabolism
OT  - obesity
EDAT- 2015/05/13 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/05/13 06:00
PHST- 2014/12/08 00:00 [received]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PST - ppublish
SO  - Diving Hyperb Med. 2015 Mar;45(1):30-6.