PMID- 25964115 OWN - NLM STAT- MEDLINE DCOM- 20160201 LR - 20220408 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 14 DP - 2015 May 13 TI - Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus. PG - 52 LID - 10.1186/s12933-015-0221-4 [doi] LID - 52 AB - OBJECTIVE: To investigate whether apolipoprotein A (apoA)-I glycation and paraoxonase (PON) activities are associated with the severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS: Relative intensity of apoA-I glycation and activities of high-density lipoprotein (HDL)-associated PON1 and PON3 were determined in 205 consecutive T2DM patients with stable angina with (n = 144) or without (n = 61) significant CAD (luminal diameter stenosis >/= 70 %). The severity of CAD was expressed by number of diseased coronary arteries, extent index, and cumulative coronary stenosis score (CCSS). RESULTS: The relative intensity of apoA-I glycation was higher but the activities of HDL-associated PON1 and PON3 were lower in diabetic patients with significant CAD than in those without. The relative intensity of apoA-I glycation increased but the activities of HDL-associated PON1 and PON3 decreased stepwise from 1 - to 3 - vessel disease patients (P for trend < 0.001). After adjusting for possible confounding variables, the relative intensity of apoA-I glycation correlated positively, while the activities of HDL-associated PON1 and PON3 negatively, with extent index and CCSS, respectively. At high level of apoA-I glycation (8.70 ~ 12.50 %), low tertile of HDL-associated PON1 (7.03 ~ 38.97U/mL) and PON3 activities (7.11 ~ 22.30U/mL) was associated with a 1.97- and 2.49- fold increase of extent index and 1.73- and 2.68- fold increase of CCSS compared with high tertile of HDL-associated PON1 (57.85 ~ 154.82U/mL) and PON3 activities (39.63 ~ 124.10U/mL), respectively (all P < 0.01). CONCLUSIONS: Elevated apoA-I glycation and decreased activities of HDL-associated PON1 and PON3, and their interaction are associated with the presence and severity of CAD in patients with T2DM. FAU - Shen, Ying AU - Shen Y AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. rjshenying@gmail.com. FAU - Ding, Feng Hua AU - Ding FH AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. ruijindfh@126.com. FAU - Sun, Jia Teng AU - Sun JT AD - Institute of Cardiovascular Disease, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. sunjiateng@hotmail.com. FAU - Pu, Li Jin AU - Pu LJ AD - Institute of Cardiovascular Disease, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. plj476@hotmail.com. FAU - Zhang, Rui Yan AU - Zhang RY AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. zhangruiyan@263.com. FAU - Zhang, Qi AU - Zhang Q AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. zhangqnh@hotmail.com. FAU - Chen, Qiu Jing AU - Chen QJ AD - Institute of Cardiovascular Disease, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. rjchenqiujing@163.com. FAU - Shen, Wei Feng AU - Shen WF AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. rjshenweifeng@126.com. AD - Institute of Cardiovascular Disease, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. rjshenweifeng@126.com. FAU - Lu, Lin AU - Lu L AD - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai, 200025, People's Republic of China. rjlulin1965@163.com. AD - Institute of Cardiovascular Disease, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. rjlulin1965@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150513 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 RN - 0 (APOA1 protein, human) RN - 0 (Apolipoprotein A-I) RN - 0 (Biomarkers) RN - 0 (Lipoproteins, HDL) RN - EC 3.1.8.1 (Aryldialkylphosphatase) RN - EC 3.1.8.1 (PON1 protein, human) RN - EC 3.1.8.1 (PON3 protein, human) SB - IM MH - Aged MH - Apolipoprotein A-I/*blood MH - Aryldialkylphosphatase/*blood MH - Biomarkers/blood MH - Coronary Artery Disease/*blood/diagnosis/epidemiology MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology MH - Enzyme Activation/physiology MH - Female MH - Humans MH - Lipoproteins, HDL/*blood MH - Male MH - Middle Aged MH - Severity of Illness Index PMC - PMC4432963 EDAT- 2015/05/13 06:00 MHDA- 2016/02/02 06:00 PMCR- 2015/05/13 CRDT- 2015/05/13 06:00 PHST- 2015/03/31 00:00 [received] PHST- 2015/04/30 00:00 [accepted] PHST- 2015/05/13 06:00 [entrez] PHST- 2015/05/13 06:00 [pubmed] PHST- 2016/02/02 06:00 [medline] PHST- 2015/05/13 00:00 [pmc-release] AID - 10.1186/s12933-015-0221-4 [pii] AID - 221 [pii] AID - 10.1186/s12933-015-0221-4 [doi] PST - epublish SO - Cardiovasc Diabetol. 2015 May 13;14:52. doi: 10.1186/s12933-015-0221-4.