PMID- 25964877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150512
LR  - 20200930
IS  - 2220-3249 (Print)
IS  - 2220-3249 (Electronic)
IS  - 2220-3249 (Linking)
VI  - 4
IP  - 2
DP  - 2015 May 12
TI  - Key role of human leukocyte antigen in modulating human immunodeficiency virus 
      progression: An overview of the possible applications.
PG  - 124-33
LID - 10.5501/wjv.v4.i2.124 [doi]
AB  - Host and viral factors deeply influence the human immunodeficiency virus (HIV) 
      disease progression. Among them human leukocyte antigen (HLA) locus plays a key 
      role at different levels. In fact, genes of the HLA locus have shown the peculiar 
      capability to modulate both innate and adaptive immune responses. In particular, 
      HLA class I molecules are recognized by CD8(+) T-cells and natural killers (NK) 
      cells towards the interaction with T cell receptor (TCR) and Killer 
      Immunoglobulin Receptor (KIR) 3DL1 respectively. Polymorphisms within the 
      different HLA alleles generate structural changes in HLA class I peptide-binding 
      pockets. Amino acid changes in the peptide-binding pocket lead to the 
      presentation of a different set of peptides to T and NK cells. This review 
      summarizes the role of HLA in HIV progression toward acquired immunodeficiency 
      disease syndrome and its receptors. Recently, many studies have been focused on 
      determining the HLA binding-peptides. The novel use of immune-informatics tools, 
      from the prediction of the HLA-bound peptides to the modification of the 
      HLA-receptor complexes, is considered. A better knowledge of HLA peptide 
      presentation and recognition are allowing new strategies for immune response 
      manipulation to be applied against HIV virus.
FAU - Grifoni, Alba
AU  - Grifoni A
AD  - Alba Grifoni, Carla Montesano, Vittorio Colizzi, Department of Biology, 
      University of Rome "Tor Vergata", 00100 Rome, Italy.
FAU - Montesano, Carla
AU  - Montesano C
AD  - Alba Grifoni, Carla Montesano, Vittorio Colizzi, Department of Biology, 
      University of Rome "Tor Vergata", 00100 Rome, Italy.
FAU - Colizzi, Vittorio
AU  - Colizzi V
AD  - Alba Grifoni, Carla Montesano, Vittorio Colizzi, Department of Biology, 
      University of Rome "Tor Vergata", 00100 Rome, Italy.
FAU - Amicosante, Massimo
AU  - Amicosante M
AD  - Alba Grifoni, Carla Montesano, Vittorio Colizzi, Department of Biology, 
      University of Rome "Tor Vergata", 00100 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Virol
JT  - World journal of virology
JID - 101608353
PMC - PMC4419116
OTO - NOTNLM
OT  - CD8+ T lymphocytes
OT  - Epitope
OT  - Human immunodeficiency virus progression
OT  - Human leukocyte antigen
OT  - Immunoinformatics
EDAT- 2015/05/13 06:00
MHDA- 2015/05/13 06:01
PMCR- 2015/05/12
CRDT- 2015/05/13 06:00
PHST- 2014/11/09 00:00 [received]
PHST- 2015/01/20 00:00 [revised]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2015/05/13 06:01 [medline]
PHST- 2015/05/12 00:00 [pmc-release]
AID - 10.5501/wjv.v4.i2.124 [doi]
PST - ppublish
SO  - World J Virol. 2015 May 12;4(2):124-33. doi: 10.5501/wjv.v4.i2.124.