PMID- 25965033
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20150616
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 527-528
DP  - 2015 Sep 15
TI  - Assessing determinants of maternal blood concentrations for persistent organic 
      pollutants and metals in the eastern and western Canadian Arctic.
PG  - 150-8
LID - S0048-9697(15)30013-9 [pii]
LID - 10.1016/j.scitotenv.2015.04.079 [doi]
AB  - Aboriginal peoples in the Canadian Arctic are exposed to persistent organic 
      pollutants (POPs) and metals mainly through their consumption of a traditional 
      diet of wildlife items. Recent studies indicate that many human chemical levels 
      have decreased in the north, likely due to a combination of reduced global 
      chemical emissions, dietary shifts, and risk mitigation efforts by local health 
      authorities. Body burdens for chemicals in mothers can be further offset by 
      breastfeeding, parity, and other maternal characteristics. We have assessed the 
      impact of several dietary and maternal covariates following a decade of awareness 
      of the contaminant issue in northern Canada, by performing multiple stepwise 
      linear regression analyses from blood concentrations and demographic variables 
      for 176 mothers recruited from Nunavut and the Northwest Territories during the 
      period 2005-2007. A significant aboriginal group effect was observed for the 
      modeled chemicals, except for lead and cadmium, after adjusting for covariates. 
      Further, blood concentrations for POPs and metals were significantly associated 
      with at least one covariate of older age, fewer months spent breastfeeding, more 
      frequent eating of traditional foods, or smoking during pregnancy. Cadmium had 
      the highest explained variance (72.5%) from just two significant covariates 
      (current smoking status and parity). Although Inuit participants from the 
      Northwest Territories consumed more traditional foods in general, Inuit 
      participants from coastal communities in Nunavut continued to demonstrate higher 
      adjusted blood concentrations for POPs and metals examined here. While this is 
      due in part to a higher prevalence of marine mammals in the eastern Arctic diet, 
      it is possible that other aboriginal group effects unrelated to diet may also 
      contribute to elevated chemical body burdens in Canadian Arctic populations.
CI  - Crown Copyright (c) 2015. Published by Elsevier B.V. All rights reserved.
FAU - Curren, Meredith S
AU  - Curren MS
AD  - Chemicals Surveillance Bureau, Healthy Environments and Consumer Safety Branch, 
      Health Canada, 269 Laurier Avenue West, Ottawa, Ontario, Canada. Electronic 
      address: meredith.curren@hc-sc.gc.ca.
FAU - Liang, Chun Lei
AU  - Liang CL
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, 50 Columbine Driveway, Tunney's Pasture, 
      Ottawa, Ontario, Canada. Electronic address: chun.lei.liang@hc-sc.gc.ca.
FAU - Davis, Karelyn
AU  - Davis K
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, 50 Columbine Driveway, Tunney's Pasture, 
      Ottawa, Ontario, Canada. Electronic address: karelyn.davis@hc-sc.gc.ca.
FAU - Kandola, Kami
AU  - Kandola K
AD  - Government of the Northwest Territories, Yellowknife, Northwest Territories, 
      Canada. Electronic address: Kami_Kandola@gov.nt.ca.
FAU - Brewster, Janet
AU  - Brewster J
AD  - Government of Nunavut, Iqaluit, Nunavut, Canada. Electronic address: 
      jbrewster@gov.nu.ca.
FAU - Potyrala, Mary
AU  - Potyrala M
AD  - Government of Nunavut, Iqaluit, Nunavut, Canada. Electronic address: 
      mary_potyrala@yahoo.ca.
FAU - Chan, Hing Man
AU  - Chan HM
AD  - Center for Advanced Research in Environmental Genomics, University of Ottawa, 20 
      Marie-Curie, Ottawa, Ontario, Canada. Electronic address: laurie.chan@uottawa.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150514
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Substances)
RN  - 0 (Metals)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Arctic Regions
MH  - Body Burden
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Hazardous Substances
MH  - Humans
MH  - Maternal Exposure/*statistics & numerical data
MH  - Metals/*blood
MH  - Northwest Territories
MH  - Nunavut
MH  - Organic Chemicals/*blood
MH  - Pregnancy
MH  - Risk Assessment
OTO - NOTNLM
OT  - Arctic
OT  - Inuit
OT  - Mercury
OT  - Persistent organic pollutants
OT  - Pregnant
EDAT- 2015/05/13 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/05/13 06:00
PHST- 2014/12/30 00:00 [received]
PHST- 2015/04/17 00:00 [revised]
PHST- 2015/04/21 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0048-9697(15)30013-9 [pii]
AID - 10.1016/j.scitotenv.2015.04.079 [doi]
PST - ppublish
SO  - Sci Total Environ. 2015 Sep 15;527-528:150-8. doi: 
      10.1016/j.scitotenv.2015.04.079. Epub 2015 May 14.