PMID- 25965183
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20181202
IS  - 1943-2704 (Electronic)
IS  - 1044-7946 (Linking)
VI  - 27
IP  - 5
DP  - 2015 May
TI  - Umbilical Cord Mesenchymal Stem Cells Combined With a Collagenfibrin 
      Double-layered Membrane Accelerates Wound Healing.
PG  - 134-40
AB  - The aim of this study was to examine the effects of human umbilical cord 
      mesenchymal stem cells (hUCMSCs) in combination with a collagen-fibrin 
      double-layered membrane on wound healing in mice. A collagen-fibrin 
      double-layered membrane was prepared, and the surface properties of the support 
      material were investigated using a scanning electron microscope. Twenty-four mice 
      were prepared for use as full-thickness skin wound models and randomly divided 
      into 3 groups: group A, a control group in which the wounds were bound using a 
      conventional method; group B, a group treated with hUCMSCs combined with a 
      collagen membrane; and group C, a group treated with hUCMSCs combined with a 
      collagen-fibrin double-layered membrane. The postoperative concrescence of the 
      wounds was observed daily to evaluate the effects of the different treatments. 
      Scanning electron microscope observation showed the collagen-fibrin scaffolds 
      exhibited a highly porous and interconnected structure, and wound healing in the 
      double-layered membrane group was better than in groups A or B. Treatment with 
      hUCMSCs combined with a collagen-fibrin double-layered membrane accelerated wound 
      healing.
FAU - Nan, Wenbin
AU  - Nan W
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China.
FAU - Liu, Rui
AU  - Liu R
AD  - Sanquan Medical College, Xinxiang Medical University, Henan, China.
FAU - Chen, Hongli
AU  - Chen H
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China.
FAU - Xu, Zhihao
AU  - Xu Z
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China.
FAU - Chen, Jiannan
AU  - Chen J
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China.
FAU - Wang, Manman
AU  - Wang M
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China.
FAU - Yuan, Zhiqing
AU  - Yuan Z
AD  - Department of Life Sciences and Technology, Xinxiang Medical University, Henan, 
      China; email: wenbinnancn@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Wounds
JT  - Wounds : a compendium of clinical research and practice
JID - 9010276
RN  - 9001-31-4 (Fibrin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Collagen/*metabolism
MH  - Dermis/blood supply/injuries/*pathology
MH  - Disease Models, Animal
MH  - Fibrin/*metabolism
MH  - Guided Tissue Regeneration
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology
MH  - Mice
MH  - Neovascularization, Physiologic
MH  - Skin/*pathology
MH  - *Tissue Engineering
MH  - Tissue Scaffolds
MH  - *Wound Healing
MH  - Wounds and Injuries/*pathology
EDAT- 2015/05/13 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/05/13 06:00
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
PST - ppublish
SO  - Wounds. 2015 May;27(5):134-40.