PMID- 25965908
OWN - NLM
STAT- MEDLINE
DCOM- 20160129
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 5
DP  - 2015
TI  - Association between Several Persistent Organic Pollutants and Thyroid Hormone 
      Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea.
PG  - e0125213
LID - 10.1371/journal.pone.0125213 [doi]
LID - e0125213
AB  - Current knowledge on adverse endocrine disruption effects of persistent organic 
      pollutants (POPs) among newborn infants is limited and often controversial. To 
      investigate the associations between prenatal exposure to major POPs and thyroid 
      hormone levels among newborn infants, both cord serum or maternal serum 
      concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl 
      ethers (PBDEs), and organochlorine pesticides (OCPs) were compared with five 
      thyroid hormones in cord serum of newborn infants as well as TSH in bloodspot 
      collected at 2 day after birth (n=104). Since cord serum thyroid hormones could 
      be affected by those of mothers, thyroid hormone concentrations of the matching 
      mothers at delivery were adjusted. In cord serum, BDE-47, -99, and Sigmachlordane 
      (CHD) showed significant positive associations with cord or bloodspot TSH. At the 
      same time, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and hexachlorbenzene 
      (HCB) showed negative associations with total T3 and total T4 in cord serum, 
      respectively. Maternal exposure to beta-hexachlorhexane (beta-HCH), SigmaCHD, SigmaDDT, or 
      p,p'-DDE were also associated with neonatal thyroid hormones. Although the sample 
      size is small and the thyroid hormone levels of the subjects were within the 
      reference range, our observation supports thyroid disrupting potential of several 
      POPs among newborn infants, at the levels occurring in the general population. 
      Considering the importance of thyroid hormones during gestation and early life 
      stages, health implication of thyroid hormone effects by low level POPs exposure 
      deserves further follow up investigations.
FAU - Kim, Sunmi
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - College of Natural Sciences, Soonchunhyang University, Asan, Chungcheong, 
      Republic of Korea.
FAU - Kim, Hai-Joong
AU  - Kim HJ
AD  - College of Medicine, Korea University, Seoul, Republic of Korea.
FAU - Lee, Jeong Jae
AU  - Lee JJ
AD  - College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  - College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
FAU - Choi, Sooran
AU  - Choi S
AD  - College of Medicine, Inha University, Incheon, Republic of Korea.
FAU - Kim, Sungjoo
AU  - Kim S
AD  - College of Medicine, Hallym University, Seoul, Republic of Korea.
FAU - Kim, Su Young
AU  - Kim SY
AD  - College of Medicine, Jeju National University, Jeju, Republic of Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - College of Science and Technology, Hanyang University, Ansan, Gyeonggi, Republic 
      of Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150512
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Chlorine Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - 0 (Thyroid Hormones)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Chlorine Compounds/blood
MH  - Endocrine Disruptors/*blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Maternal Exposure
MH  - Maternal-Fetal Exchange
MH  - Middle Aged
MH  - Pesticides/blood/chemistry
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
MH  - Republic of Korea
MH  - Thyroid Hormones/*blood
PMC - PMC4429016
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/05/13 06:00
MHDA- 2016/01/30 06:00
PMCR- 2015/05/12
CRDT- 2015/05/13 06:00
PHST- 2014/08/28 00:00 [received]
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/01/30 06:00 [medline]
PHST- 2015/05/12 00:00 [pmc-release]
AID - PONE-D-14-38147 [pii]
AID - 10.1371/journal.pone.0125213 [doi]
PST - epublish
SO  - PLoS One. 2015 May 12;10(5):e0125213. doi: 10.1371/journal.pone.0125213. 
      eCollection 2015.