PMID- 2596606
OWN - NLM
STAT- MEDLINE
DCOM- 19900112
LR  - 20181130
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 257
IP  - 5 Pt 1
DP  - 1989 Nov
TI  - Gastric response to mucosal IgE-mediated reactions.
PG  - G704-8
AB  - The effect of immunoglobulin E (IgE)-mediated anaphylaxis has been extensively 
      studied in the small intestine, but little information is available on the 
      response of the stomach to IgE-mediated mucosal reactions to food proteins. The 
      effect of luminal antigenic challenge on gastric acid secretion, gastric 
      emptying, and mucosal mast cell degranulation was examined in rats sensitized to 
      egg albumin or in sham-treated controls. Intraluminal challenge of the stomach 
      with egg albumin in sensitized animals significantly increased gastric acid 
      secretion and delayed gastric emptying. The response was specific for the 
      sensitizing antigen as challenge with bovine serum albumin was without effect. 
      Sham-treated animals showed no response to egg albumin or bovine serum albumin. 
      The increase in gastric acid secretion was reproduced by antigen challenge in 
      naive animals passively transferred with hyperimmune serum. This effect was 
      abolished by prior heat treatment of the serum. In sensitized animals challenged 
      with egg albumin, there was histological evidence of mast cell degranulation in 
      the stomach mucosa, increased intraluminal release of histamine, and increased 
      serum levels of rat mast cell protease II, a marker specific for mucosal mast 
      cell degranulation. The findings indicate that the stomach is a target organ for 
      IgE-mediated reactions to food proteins. Antigen challenge in sensitized animals 
      leads to increased gastric acid secretion and delayed emptying and evidence of 
      mucosal mast cell activation.
FAU - Catto-Smith, A G
AU  - Catto-Smith AG
AD  - Gastrointestinal Research Group, University of Calgary, Alberta, Canada.
FAU - Patrick, M K
AU  - Patrick MK
FAU - Scott, R B
AU  - Scott RB
FAU - Davison, J S
AU  - Davison JS
FAU - Gall, D G
AU  - Gall DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Cell Count
MH  - Female
MH  - Gastric Acid/metabolism
MH  - Gastric Emptying
MH  - Gastric Mucosa/cytology/immunology/*metabolism
MH  - Immunoglobulin E/*physiology
MH  - Mast Cells/cytology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stomach/*physiology
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1152/ajpgi.1989.257.5.G704 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Nov;257(5 Pt 1):G704-8. doi: 10.1152/ajpgi.1989.257.5.G704.