PMID- 25966159
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20150513
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 2
DP  - 2015 Apr 27
TI  - Serum immunoglobulin E level and its impact on the pregnancy outcome associated 
      with fetal growth restriction: a prospective cohort study.
PG  - 3879-88
LID - 10.4238/2015.April.27.2 [doi]
AB  - We evaluated the relationship between total serum immunoglobulin E (IgE) levels 
      and pregnancy outcome in a prospective cohort study focusing on fetal growth 
      restriction (FGR). Sixty women with FGR and twenty with normal singleton 
      pregnancy were enrolled during their third trimester. Infants were followed up 
      for 6 months. Blood samples were obtained from pregnant women during the third 
      trimester; cord blood samples were also taken. Six months after birth, blood 
      samples were obtained from infants. Demographic and baseline characteristics were 
      compared between groups. Birth weight, length and head circumference of neonates 
      in the FGR group were lower than those in the control group. Total serum IgE 
      level was significantly increased in third-trimester pregnant women with FGR 
      compared with normal group (P < 0.05). However, this trend was not observed in 
      the cord blood at birth or peripheral blood of 6-month-old infants. The 
      prevalence of atopic eczema between the 2 groups was similar. Linear regression 
      analysis revealed that the IgE level in the third trimester was negatively 
      correlated with birth weight (P < 0.05). Higher serum IgE level in the cord blood 
      was significantly associated with an increased risk of being small for 
      gestational age (P < 0.05). In conclusion, IgE levels in the third trimester of 
      pregnancy and cord blood are strongly related to birth outcomes of FGR.
FAU - Xiong, F
AU  - Xiong F
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, China.
FAU - Tong, Y
AU  - Tong Y
AD  - Laboratory of Early Developmental and Injuries, West China Institute of Woman and 
      Children's Health, West China Second University Hospital, Sichuan University, 
      China.
FAU - Li, P
AU  - Li P
AD  - Laboratory of Early Developmental and Injuries, West China Institute of Woman and 
      Children's Health, West China Second University Hospital, Sichuan University, 
      China.
FAU - Huo, T
AU  - Huo T
AD  - Laboratory of Early Developmental and Injuries, West China Institute of Woman and 
      Children's Health, West China Second University Hospital, Sichuan University, 
      China.
FAU - Mao, M
AU  - Mao M
AD  - Laboratory of Early Developmental and Injuries, West China Institute of Woman and 
      Children's Health, West China Second University Hospital, Sichuan University, 
      China dffmmao@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150427
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - *Fetal Growth Retardation
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Prospective Studies
EDAT- 2015/05/13 06:00
MHDA- 2016/02/09 06:00
CRDT- 2015/05/13 06:00
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - gmr3495 [pii]
AID - 10.4238/2015.April.27.2 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Apr 27;14(2):3879-88. doi: 10.4238/2015.April.27.2.