PMID- 25966203
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20171116
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 2
DP  - 2015 Apr 30
TI  - Association of CD14 C159T polymorphism with atopic asthma susceptibility in 
      children from Southeastern China: a case-control study.
PG  - 4311-7
LID - 10.4238/2015.April.30.3 [doi]
AB  - CD14 is involved in primary immune and inflammatory responses. The -159 C/T 
      variation in the CD14 gene plays an important role in regulating CD14 expression 
      and has been associated with the susceptibility to various diseases, including 
      allergies. In this study, we examined the association between the C-159T 
      polymorphism and atopic asthma susceptibility in children from Southeastern 
      China. The study population included 746 unrelated children of Chinese Han 
      nationality (362 patients with atopic asthma and 384 healthy controls). CD14 gene 
      polymorphisms were identified by direct sequencing of polymerase chain reaction 
      products. Total immunoglobulin E (IgE) levels in human serum samples were 
      determined using an enzyme-linked immunosorbent assay. Individuals carrying the 
      TT genotypes for rs2569190 were significantly associated with an increased risk 
      of atopic asthma compared with those carrying the wild-type homozygous CC 
      genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 
      0.025]. Total serum IgE levels in TT genotype carriers were significantly higher 
      than those in CC genotype carriers in atopic asthma patients (286.3 +/- 161.5 IU/mL 
      vs 248.3 +/- 147.8 IU/mL). Our data suggest that the CD14 TT genotype may be a 
      genetic susceptibility marker for atopic asthma in Chinese Han children.
FAU - Zhang, Y N
AU  - Zhang YN
AD  - Department of Clinical Laboratory, The Taixing People's Hospital, Taixing, 
      Jiangsu, China.
FAU - Li, Y J
AU  - Li YJ
AD  - Department of Clinical Laboratory, The Taixing People's Hospital, Taixing, 
      Jiangsu, China.
FAU - Li, H
AU  - Li H
AD  - Department of Clinical Laboratory, The Taixing People's Hospital, Taixing, 
      Jiangsu, China.
FAU - Zhou, H
AU  - Zhou H
AD  - Department of Clinical Laboratory, Affiliated Children's Hospital, Soochow 
      University, Suzhou, Jiangsu, China.
FAU - Shao, X J
AU  - Shao XJ
AD  - Department of Clinical Laboratory, Affiliated Children's Hospital, Soochow 
      University, Suzhou, Jiangsu, China xuejunshao2014@163.com.
LA  - eng
PT  - Journal Article
DEP - 20150430
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*genetics
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lipopolysaccharide Receptors/*genetics
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Sequence Analysis, DNA
EDAT- 2015/05/13 06:00
MHDA- 2016/02/19 06:00
CRDT- 2015/05/13 06:00
PHST- 2015/05/13 06:00 [entrez]
PHST- 2015/05/13 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - gmr4746 [pii]
AID - 10.4238/2015.April.30.3 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Apr 30;14(2):4311-7. doi: 10.4238/2015.April.30.3.