PMID- 25966899
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20150825
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 230
IP  - 12
DP  - 2015 Dec
TI  - Revisiting Chaos Theorem to Understand the Nature of miRNAs in Response to Drugs 
      of Abuse.
PG  - 2857-68
LID - 10.1002/jcp.25037 [doi]
AB  - Just like Matryoshka dolls, biological systems follow a hierarchical order that 
      is based on dynamic bidirectional communication among its components. In addition 
      to the convoluted inter-relationships, the complexity of each component spans 
      several folds. Therefore, it becomes rather challenging to investigate phenotypes 
      resulting from these networks as it requires the integration of reductionistic 
      and holistic approaches. One dynamic system is the transcriptome which comprises 
      a variety of RNA species. Some, like microRNAs, have recently received a lot of 
      attention. miRNAs are very pleiotropic and have been considered as therapeutic 
      and diagnostic candidates in the biomedical fields. In this review, we survey 
      miRNA profiles in response to drugs of abuse (DA) using 118 studies. After 
      providing a summary of miRNAs related to substance use disorders (SUD), general 
      patterns of miRNA signatures are compared among studies for single or multiple 
      drugs of abuse. Then, current challenges and drawbacks in the field are 
      discussed. Finally, we provide support for considering miRNAs as a chaotic system 
      in normal versus disrupted states particularly in SUD and propose an integrative 
      approach for studying and analyzing miRNA data.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Taki, Faten A
AU  - Taki FA
AD  - Department of Biology, East Carolina University, Greenville, North Carolina.
FAU - Pan, Xiaoping
AU  - Pan X
AD  - Department of Biology, East Carolina University, Greenville, North Carolina.
FAU - Zhang, Baohong
AU  - Zhang B
AD  - Department of Biology, East Carolina University, Greenville, North Carolina.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Genetic Markers)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Gene Expression Profiling/methods
MH  - Gene Expression Regulation/drug effects
MH  - *Genetic Markers
MH  - Humans
MH  - MicroRNAs/*genetics/metabolism
MH  - *Models, Genetic
MH  - *Nonlinear Dynamics
MH  - Substance-Related Disorders/*genetics/metabolism
EDAT- 2015/05/15 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/05/14 06:00
PHST- 2015/03/27 00:00 [received]
PHST- 2015/05/05 00:00 [accepted]
PHST- 2015/05/14 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - 10.1002/jcp.25037 [doi]
PST - ppublish
SO  - J Cell Physiol. 2015 Dec;230(12):2857-68. doi: 10.1002/jcp.25037.