PMID- 25967685
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20150513
IS  - 0873-2159 (Print)
IS  - 0873-2159 (Linking)
VI  - 14 Suppl 3
DP  - 2008 Oct
TI  - Erlotinib and brain metastases.
PG  - S35-42
LID - S0873-2159(15)30320-2 [pii]
LID - 10.1016/S0873-2159(15)30320-2 [doi]
AB  - We report two cases of brain metastases in context of non small cell lung cancer 
      (NSCLC). After having progressed to chemotherapy they received erlotinib 150mg/m2 
      orally daily, with complete response of brain metastasis and partial response of 
      thoracic lesions. Brain metastases are both prevalent and a major cause of 
      mortality in NSCLC, with few systemic treatment options. Median survival after 
      whole brain radiotherapy is 4-6 months and the role of systemic therapy for brain 
      metastases is limited with the most drugs use to stage IV disease ineffective in 
      this setting. This case demonstrates that brain metastases may be sensitive to 
      erlotinib and give to us growing body of evidence that EGFR-associated tyrosine 
      kinase inhibition is a feasible strategy in the management of NSCLC patients with 
      brain metastases We propose further study into the continued use of this drug in 
      the situation where there is a differential response. Rev Port Pneumol 2008; XIV 
      (Supl 3): S35-S42.
CI  - (c) 2008 Sociedade Portuguesa de Pneumologia/SPP.
FAU - Barata, Fernando
AU  - Barata F
AD  - Servico de Pneumologia. Centro Hospitalar de Coimbra.
FAU - Costa, Teresa
AU  - Costa T
AD  - Servico de Pneumologia. Centro Hospitalar de Coimbra.
FAU - Figueiredo, Ana
AU  - Figueiredo A
AD  - Servico de Pneumologia. Centro Hospitalar de Coimbra.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Erlotinib e metastases cerebrais.
PL  - Spain
TA  - Rev Port Pneumol
JT  - Revista portuguesa de pneumologia
JID - 9813736
OTO - NOTNLM
OT  - Erlotinib
OT  - brain metastasis
OT  - cancro do pulmao
OT  - lung cancer
OT  - metastase cerebral
EDAT- 2008/10/01 00:00
MHDA- 2008/10/01 00:01
CRDT- 2015/05/14 06:00
PHST- 2015/05/14 06:00 [entrez]
PHST- 2008/10/01 00:00 [pubmed]
PHST- 2008/10/01 00:01 [medline]
AID - S0873-2159(15)30320-2 [pii]
AID - 10.1016/S0873-2159(15)30320-2 [doi]
PST - ppublish
SO  - Rev Port Pneumol. 2008 Oct;14 Suppl 3:S35-42. doi: 10.1016/S0873-2159(15)30320-2.