PMID- 25967955
OWN - NLM
STAT- MEDLINE
DCOM- 20160726
LR  - 20150828
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 61
IP  - 5
DP  - 2015 Sep-Oct
TI  - Continuous Flow Device Support in Children Using the HeartWare HVAD: 1,000 Days 
      of Lessons Learned From a Single Center Experience.
PG  - 569-73
LID - 10.1097/MAT.0000000000000253 [doi]
AB  - The purpose of this study is to provide a single center experience with a 
      continuous flow device in adolescents with end-stage heart failure. A 
      retrospective single center analysis of patients aged 18 years or younger 
      implanted with HVAD (HeartWare Inc, Framingham, MA) between October 2012 and 
      March 2014 was performed. Demographics, preimplant and postimplant clinical data, 
      survival, and adverse events (AEs) were recorded. A matched group of adults based 
      on diagnosis, body surface area (BSA), and time period were used for outcome 
      comparisons. Six adolescents with dilated cardiomyopathy were implanted with the 
      HVAD. Median age and BSA were 13.4 years and 1.45 m2, respectively. All were 
      Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 
      profile-1 or profile-2. Median days on device were 108 with total patient-days on 
      device of 1,017. Four adolescents were discharged home on device all in New York 
      Heart Association 1. Five underwent transplantation with 100% survival. There 
      were 18 AEs with one AE per 170 days on device. Compared with the adult cohort (n 
      = 5), there was no difference in 1 year survival (p = 0.32). HVAD support in 
      adolescents is highly successful as a bridge to transplantation. It provides 
      early rehabilitation and improvement in quality of life. Morbidity is not 
      negligible but appears comparable with that seen in adults.
FAU - Sparks, Joshua
AU  - Sparks J
AD  - From the *Division of Pediatric Cardiology, Department of Pediatrics, University 
      of Louisville, Louisville, Kentucky; daggerDivision of Cardiothoracic Surgery, 
      Department of Surgery, double daggerDivision of Pediatric Critical Care, Department of 
      Pediatrics, Washington University School of Medicine St. Louis, Missouri; 
       section signDepartment of Critical Care, St. Louis Children's Hospital, St. Louis, Missouri; 
      and  paragraph signDivision of Pediatric Cardiology, Department of Pediatrics, Washington 
      University School of Medicine, St. Louis, Missouri.
FAU - Epstein, Deirdre
AU  - Epstein D
FAU - Baltagi, Sirine
AU  - Baltagi S
FAU - Mehegan, Mary E
AU  - Mehegan ME
FAU - Simpson, Kathleen E
AU  - Simpson KE
FAU - Canter, Charles E
AU  - Canter CE
FAU - Silvestry, Scott
AU  - Silvestry S
FAU - Eghtesady, Pirooz
AU  - Eghtesady P
FAU - Boston, Umar S
AU  - Boston US
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Circulation/physiology
MH  - Cardiomyopathies/*surgery
MH  - Child
MH  - Female
MH  - Heart Failure/*surgery
MH  - Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Retrospective Studies
EDAT- 2015/05/15 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/05/14 06:00
PHST- 2015/05/14 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1097/MAT.0000000000000253 [doi]
PST - ppublish
SO  - ASAIO J. 2015 Sep-Oct;61(5):569-73. doi: 10.1097/MAT.0000000000000253.