PMID- 25969153
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20221207
IS  - 1661-6758 (Electronic)
IS  - 1661-6499 (Linking)
VI  - 7
IP  - 4-6
DP  - 2014
TI  - Interaction between Erythrocyte Phospholipid Fatty Acids Composition and Variants 
      of Inflammation-Related Genes on Type 2 Diabetes.
PG  - 252-63
LID - 10.1159/000381347 [doi]
AB  - AIMS: The present study aimed to investigate the interaction between erythrocyte 
      phospholipid (PL) fatty acids and variants of inflammation-related genes in a 
      Chinese population. METHODS: A total of 622 patients with type 2 diabetes 
      mellitus (T2DM) and 293 healthy subjects were included. Determination of 
      erythrocyte PL fatty acids composition and genotyping of single nucleotide 
      polymorphisms were conducted by standard methods. RESULTS: A significant 
      interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T 
      allele carriers (TT+CT) had a higher risk of T2DM than noncarriers only when they 
      had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 
      (95% CI 1.58-4.24; p for interaction=0.005) and 2.49 (95% CI 1.47-4.24; p for 
      interaction=0.021), respectively. A significant interaction of rs8078723 at the 
      intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele 
      carriers (CC+CT) had a lower risk of T2DM than noncarriers only when they had a 
      higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for 
      interaction=0.014). CONCLUSIONS: rs7305618 and rs8078723 were associated with the 
      risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty 
      acids composition.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Li, Kelei
AU  - Li K
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, PR 
      China.
FAU - Huang, Tao
AU  - Huang T
FAU - Zheng, Ju-Sheng
AU  - Zheng JS
FAU - Sun, Jianqin
AU  - Sun J
FAU - Chen, Yanqiu
AU  - Chen Y
FAU - Xie, Hua
AU  - Xie H
FAU - Xu, Danfeng
AU  - Xu D
FAU - Wan, Jianbo
AU  - Wan J
FAU - Li, Duo
AU  - Li D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150507
PL  - Switzerland
TA  - J Nutrigenet Nutrigenomics
JT  - Journal of nutrigenetics and nutrigenomics
JID - 101299758
RN  - 0 (Fatty Acids)
RN  - 0 (HNF1A protein, human)
RN  - 0 (Hepatocyte Nuclear Factor 1-alpha)
RN  - 0 (Phospholipids)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - EC 3.4.25.1 (proteasome activator PA700 subunit p58, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*blood/*genetics
MH  - Erythrocytes/metabolism
MH  - Fatty Acids/*blood
MH  - Female
MH  - Genotype
MH  - Granulocyte Colony-Stimulating Factor/genetics
MH  - Hepatocyte Nuclear Factor 1-alpha/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrigenomics
MH  - Phospholipids/*blood
MH  - *Polymorphism, Single Nucleotide
MH  - Proteasome Endopeptidase Complex/genetics
MH  - Risk Factors
EDAT- 2015/05/15 06:00
MHDA- 2016/04/23 06:00
CRDT- 2015/05/14 06:00
PHST- 2015/05/14 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 000381347 [pii]
AID - 10.1159/000381347 [doi]
PST - ppublish
SO  - J Nutrigenet Nutrigenomics. 2014;7(4-6):252-63. doi: 10.1159/000381347. Epub 2015 
      May 7.