PMID- 25970075
OWN - NLM
STAT- MEDLINE
DCOM- 20160727
LR  - 20221207
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 54
IP  - 11
DP  - 2015 Nov
TI  - Toxic epidermal necrolysis induced by methazolamide in a Chinese-Korean man 
      carrying HLA-B*59:01.
PG  - 1242-5
LID - 10.1111/ijd.12651 [doi]
AB  - BACKGROUND: Methazolamide is used to lower intraocular pressure in patients with 
      glaucoma. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) 
      associated with methazolamide treatment have been diagnosed in Korean, Japanese, 
      and Japanese-American patients. According to recent research, the human leukocyte 
      antigen (HLA) allele HLA-B*59:01 is strongly linked to SJS/TEN associated with 
      methazolamide treatment. OBJECTIVE: A patient of Chinese-Korean ethnicity was 
      diagnosed with TEN associated with methazolamide treatment. The purpose of this 
      study was to examine the potential genetic basis of this disease. METHODS: A 
      polymerase chain reaction sequence-specific primer (PCR-SSP) typing system was 
      used to genotype this patient's peripheral blood DNA for HLA-B*59. RESULTS: The 
      genotype HLA-B*59:01 was detected in the patient. CONCLUSIONS: This study 
      demonstrates the genotype of HLA-B*59:01 in a patient with TEN associated with 
      methazolamide treatment and thus supports the possible correlation between 
      genetic background and methazolamide-associated SJS/TEN.
CI  - (c) 2015 The International Society of Dermatology.
FAU - Shu, Chang
AU  - Shu C
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Shu, Dan
AU  - Shu D
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Tie, Duerna
AU  - Tie D
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Yu, Mengqing
AU  - Yu M
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Wang, Tong
AU  - Wang T
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Dong, Qi
AU  - Dong Q
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Sun, Qiuning
AU  - Sun Q
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Mao, Xuming
AU  - Mao X
AD  - Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Yan, Yan
AU  - Yan Y
AD  - Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150513
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B59 antigen)
RN  - W733B0S9SD (Methazolamide)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People
MH  - Carbonic Anhydrase Inhibitors/*adverse effects
MH  - China/ethnology
MH  - Genotype
MH  - Glaucoma/drug therapy
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Methazolamide/*adverse effects
MH  - Republic of Korea/ethnology
MH  - Stevens-Johnson Syndrome/drug therapy/*etiology/genetics
EDAT- 2015/05/15 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/05/14 06:00
PHST- 2013/12/21 00:00 [received]
PHST- 2013/12/29 00:00 [revised]
PHST- 2014/01/12 00:00 [accepted]
PHST- 2015/05/14 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1111/ijd.12651 [doi]
PST - ppublish
SO  - Int J Dermatol. 2015 Nov;54(11):1242-5. doi: 10.1111/ijd.12651. Epub 2015 May 13.