PMID- 25970861
OWN - NLM
STAT- MEDLINE
DCOM- 20151023
LR  - 20220310
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 46
IP  - 4
DP  - 2015 Apr
TI  - Comparison of Geographic Atrophy Growth Rates Using Different Imaging Modalities 
      in the COMPLETE Study.
PG  - 413-22
LID - 10.3928/23258160-20150422-03 [doi]
AB  - BACKGROUND AND OBJECTIVE: To compare the measurements and growth rates of 
      geographic atrophy (GA) secondary to age-related macular degeneration (AMD) 
      obtained using different imaging modalities. PATIENTS AND METHODS: Thirty 
      patients with AMD and GA measuring from 1.25 mm(2) to 18 mm(2) based on 
      spectral-domain optical coherence tomography (SD-OCT) fundus imaging were 
      enrolled. Imaging was performed at baseline and at follow-up months 3, 6, 9, and 
      12, including autofluorescence (AF) imaging with a fundus camera-based flash 
      system (TRC-50DX; Topcon Medical Systems, Oakland, NJ; AF excitation lambda: 535-585 
      nm; detection lambda: 605-715 nm), AF and fluorescein angiography (FA) imaging with a 
      confocal scanning laser ophthalmoscopy (SLO) system (Spectralis; Heidelberg 
      Engineering, Heidelberg, Germany; AF excitation lambda: 488 nm; detection lambda: > 500 
      nm), and SD-OCT en face imaging (Cirrus; Carl Zeiss Meditec, Dublin, CA). 
      RESULTS: Average baseline square root measurements and enlargement rates of 
      square root areas appeared similar across all modalities; 0.2 mm was the largest 
      difference between any pair of measurement means. The intraclass correlation 
      coefficients (ICC) were essentially equal to 1 for all comparisons of area 
      measurements but were lower for growth rates than area measurements. Comparison 
      of 26-week average enlargement rates showed no significant difference between the 
      SLO AF image and enhanced SD-OCT en face image (mean difference: 0.01 mm; SD: 
      0.10; P = .70). CONCLUSION: Agreement among all imaging modalities in measuring 
      the areas of GA at baseline diminished when the growth rates of GA were compared 
      over 26 weeks, likely because each imaging technique identifies different 
      anatomic features along the border of GA, which may appear similar but change at 
      different rates.
CI  - Copyright 2015, SLACK Incorporated.
FAU - Yehoshua, Zohar
AU  - Yehoshua Z
FAU - de Amorim Garcia Filho, Carlos Alexandre
AU  - de Amorim Garcia Filho CA
FAU - Nunes, Renata Portella
AU  - Nunes RP
FAU - Gregori, Giovanni
AU  - Gregori G
FAU - Penha, Fernando M
AU  - Penha FM
FAU - Moshfeghi, Andrew A
AU  - Moshfeghi AA
FAU - Sadda, SriniVas
AU  - Sadda S
FAU - Feuer, William
AU  - Feuer W
FAU - Rosenfeld, Philip J
AU  - Rosenfeld PJ
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Complement Inactivating Agents)
RN  - A3ULP0F556 (eculizumab)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal, Humanized/therapeutic use
MH  - Complement Inactivating Agents/therapeutic use
MH  - Double-Blind Method
MH  - Fluorescein Angiography
MH  - Geographic Atrophy/classification/*diagnosis/drug therapy
MH  - Humans
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - Ophthalmoscopy
MH  - Optical Imaging
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence
EDAT- 2015/05/15 06:00
MHDA- 2015/10/24 06:00
CRDT- 2015/05/14 06:00
PHST- 2014/05/18 00:00 [received]
PHST- 2015/02/06 00:00 [accepted]
PHST- 2015/05/14 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2015/10/24 06:00 [medline]
AID - 10.3928/23258160-20150422-03 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2015 Apr;46(4):413-22. doi: 
      10.3928/23258160-20150422-03.