PMID- 25971394
OWN - NLM
STAT- MEDLINE
DCOM- 20151218
LR  - 20181202
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 15
DP  - 2015 Jan 21
TI  - The influence of mild hypothermia on reversal of rocuronium-induced deep 
      neuromuscular block with sugammadex.
PG  - 7
LID - 10.1186/1471-2253-15-7 [doi]
LID - 7
AB  - BACKGROUND: Mild hypothermia may be frequently induced due to cool environments 
      in the operating room. The study analyzed patient recovery time and response to 
      sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) 
      during mild hypothermia. METHODS: Sixty patients were randomly (1:1) allocated to 
      the mild hypothermia and normothermia groups, defined as having core temperatures 
      between 34.5-35 degrees C and 36.5-37 degrees C, respectively. Patients received 0.6 mg/kg of 
      rocuronium, followed by 7-10 mug/kg/min to maintain a deep NMB [post-tetanic count 
      (PTC) 1-2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. 
      The primary end-point was the time until the train-of-four (TOF) ratio was 0.9. 
      RESULTS: The appropriate neuromuscular function (TOF ratio >/= 0.9) was restored 
      after sugammadex was administered, even after hypothermia. The length of recovery 
      in the hypothermia patients [mean (SD), 171.1 (62.1) seconds (s)] was 
      significantly slower compared with the normothermia patients [124.9 (59.2) s] 
      (p = 0.005). There were no adverse effects from sugammadex. CONCLUSIONS: 
      Sugammadex safely and securely reversed deep rocuronium-induced NMB during mild 
      hypothermia. An additional 46 s was required for recovery from a deep NMB in 
      hypothermia patients. Based on the results, we think this prolonged recovery time 
      is clinically acceptable. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: 
      NCT01965067.
FAU - Lee, Hee Jong
AU  - Lee HJ
AD  - Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, #17 
      Haengdang dong, Sungdong gu, Seoul, 133-792, Korea. makeitcool@hanmail.net.
FAU - Kim, Kyo Sang
AU  - Kim KS
AD  - Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, #17 
      Haengdang dong, Sungdong gu, Seoul, 133-792, Korea. kimks@hanyang.ac.kr.
FAU - Jeong, Ji Seon
AU  - Jeong JS
AD  - Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Seoul, 
      Korea. wltjs78@hanmail.net.
FAU - Kim, Kyu Nam
AU  - Kim KN
AD  - Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, #17 
      Haengdang dong, Sungdong gu, Seoul, 133-792, Korea. vesicle100@naver.com.
FAU - Lee, Byeong Chan
AU  - Lee BC
AD  - Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, #17 
      Haengdang dong, Sungdong gu, Seoul, 133-792, Korea. awetkiss@naver.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT01965067
PT  - Clinical Trial, Phase IV
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150121
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
RN  - 0 (Androstanols)
RN  - 0 (Neuromuscular Nondepolarizing Agents)
RN  - 0 (gamma-Cyclodextrins)
RN  - 361LPM2T56 (Sugammadex)
RN  - WRE554RFEZ (Rocuronium)
SB  - IM
MH  - Adult
MH  - *Androstanols
MH  - Anesthesia Recovery Period
MH  - Blood Pressure/drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypothermia/*complications
MH  - Male
MH  - Middle Aged
MH  - Neuromuscular Blockade/*methods
MH  - *Neuromuscular Nondepolarizing Agents
MH  - Rocuronium
MH  - Sugammadex
MH  - Young Adult
MH  - gamma-Cyclodextrins/*therapeutic use
PMC - PMC4430027
EDAT- 2015/05/15 06:00
MHDA- 2015/12/19 06:00
PMCR- 2015/01/21
CRDT- 2015/05/15 06:00
PHST- 2014/09/26 00:00 [received]
PHST- 2015/01/15 00:00 [accepted]
PHST- 2015/05/15 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
PHST- 2015/01/21 00:00 [pmc-release]
AID - 10.1186/1471-2253-15-7 [pii]
AID - 366 [pii]
AID - 10.1186/1471-2253-15-7 [doi]
PST - epublish
SO  - BMC Anesthesiol. 2015 Jan 21;15:7. doi: 10.1186/1471-2253-15-7.