PMID- 25972163
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20181113
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 35
IP  - 19
DP  - 2015 May 13
TI  - Consolidation of Associative and Item Memory Is Related to Post-Encoding 
      Functional Connectivity between the Ventral Tegmental Area and Different Medial 
      Temporal Lobe Subregions during an Unrelated Task.
PG  - 7326-31
LID - 10.1523/JNEUROSCI.4816-14.2015 [doi]
AB  - It is well established that the hippocampus and perirhinal cortex (PrC) encode 
      associative and item representations, respectively. However, less is known about 
      how item and associative memories are consolidated. We used high-resolution fMRI 
      in humans to measure how functional connectivity between these distinct medial 
      temporal lobe regions with the ventral tegmental area (VTA) after a paired 
      associate encoding task is related to both immediate and 24 h item and 
      associative memory performance. We found that the strength of post-encoding 
      functional connectivity between the VTA and CA1 selectively correlated with 
      long-term associative memory, despite subjects actively engaging in an unrelated 
      task during this period. Conversely, VTA-PrC functional connectivity during the 
      same period correlated with long-term item memory. Critically, connectivity 
      between VTA and these MTL regions were only related to memory tested at a 24 h 
      delay, implicating midbrain connectivity in the consolidation of distinct forms 
      of memory.
CI  - Copyright (c) 2015 the authors 0270-6474/15/357326-06$15.00/0.
FAU - Tompary, Alexa
AU  - Tompary A
AD  - Department of Psychology and.
FAU - Duncan, Katherine
AU  - Duncan K
AD  - Department of Psychology, Columbia University, New York, New York 10027.
FAU - Davachi, Lila
AU  - Davachi L
AD  - Department of Psychology and Center for Neural Science, New York University, New 
      York, New York 10003 and lila.davachi@nyu.edu.
LA  - eng
GR  - R01 MH074692/MH/NIMH NIH HHS/United States
GR  - MH074692/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Association Learning/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mathematics
MH  - Memory/*physiology
MH  - Neural Pathways/blood supply/*physiology
MH  - Oxygen/blood
MH  - Problem Solving/physiology
MH  - Statistics as Topic
MH  - Temporal Lobe/blood supply/*physiology
MH  - Ventral Tegmental Area/blood supply/*physiology
MH  - Young Adult
PMC - PMC4429149
OTO - NOTNLM
OT  - VTA
OT  - consolidation
OT  - functional connectivity
OT  - high-resolution fMRI
OT  - medial temporal lobe
EDAT- 2015/05/15 06:00
MHDA- 2015/07/28 06:00
PMCR- 2015/11/13
CRDT- 2015/05/15 06:00
PHST- 2015/05/15 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
PHST- 2015/11/13 00:00 [pmc-release]
AID - 35/19/7326 [pii]
AID - 4816-14 [pii]
AID - 10.1523/JNEUROSCI.4816-14.2015 [doi]
PST - ppublish
SO  - J Neurosci. 2015 May 13;35(19):7326-31. doi: 10.1523/JNEUROSCI.4816-14.2015.