PMID- 25973105
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 2
DP  - 2015
TI  - Significance of plasma hepatocyte growth factor in diagnosis of benign and 
      malignant solitary pulmonary nodules.
PG  - 2063-7
AB  - PURPOSE: We aimed to figure out the difference of serum hepatocyte growth factor 
      (S-HGF) level between benign and malignant solitary pulmonary nodules (SPNs) 
      patients. METHODS: The study comprised 42 serum samples from SPNs patients and 10 
      serum samples of healthy donors. The HGF level was measured by the commercially 
      enzyme-linked immunosorbent assay (ELISA) kit. RESULTS: By statistical analysis, 
      the S-HGF levels of the malignant SPNs patients were significantly higher than 
      that of control group (P < 0.05). Moreover, the levels of S-HGF in malignant 
      group were also significantly higher than that in benign group (P < 0.05), while 
      there was no significant difference between the benign and control group (P > 
      0.05). The levels of S-HGF were also shown no statistically significant 
      difference (P > 0.05) in different pathologic types of lung cancer patients. In 
      addition, the incidence of malignant SPNs increased when the S-HGF level >/= 250 
      pg/ml. CONCLUSION: The detection of S-HGF level may be a new detection method 
      used for the rapid diagnosis of benign and malignant SPNs.
FAU - Yu, Haixin
AU  - Yu H
AD  - Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University 
      Changchun 130033, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University 
      Changchun 130033, China.
FAU - Yu, Qian
AU  - Yu Q
AD  - Department of Pharmacy, China-Japan Union Hospital of Jilin University Changchun 
      130033, China.
FAU - Zhang, Haiyan
AU  - Zhang H
AD  - Department of Pharmacy, China-Japan Union Hospital of Jilin University Changchun 
      130033, China.
FAU - Ma, Wenduan
AU  - Ma W
AD  - Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University 
      Changchun 130033, China.
FAU - Shang, Shengtao
AU  - Shang S
AD  - Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University 
      Changchun 130033, China.
FAU - Wang, Donglin
AU  - Wang D
AD  - Green Garden District Changchun City Hospital No. 1015, Chuncheng Avenue, 
      Changchun 130062, China.
LA  - eng
PT  - Journal Article
DEP - 20150201
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Diagnosis, Differential
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - Lung Neoplasms/blood/*diagnosis
MH  - Solitary Pulmonary Nodule/blood/*diagnosis
PMC - PMC4396333
OTO - NOTNLM
OT  - Diagnosis
OT  - hepatocyte growth factor
OT  - solitary pulmonary nodules
EDAT- 2015/05/15 06:00
MHDA- 2016/02/13 06:00
PMCR- 2015/02/01
CRDT- 2015/05/15 06:00
PHST- 2014/12/05 00:00 [received]
PHST- 2015/01/23 00:00 [accepted]
PHST- 2015/05/15 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Feb 1;8(2):2063-7. eCollection 2015.