PMID- 25973737
OWN - NLM
STAT- MEDLINE
DCOM- 20160322
LR  - 20200225
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 38
IP  - 6
DP  - 2015 Jun
TI  - Increased Transforming Growth Factor-beta Levels Associated With Cardiac Adverse 
      Events in Hypertrophic Cardiomyopathy.
PG  - 371-7
LID - 10.1002/clc.22404 [doi]
AB  - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease 
      characterized by ventricular hypertrophy, myocardial fibrosis, and impaired 
      ventricular relaxation. The exact mechanisms by which fibrosis is caused remain 
      unknown. HYPOTHESIS: Circulating TGF-beta is related to poor prognosis in HCM. 
      METHODS: We compared TGF-beta levels of 49 HCM patients with those of 40 non-HCM 
      patients. We followed the patients with HCM for 18 months and divided them into 2 
      groups: low TGF-beta (</= 4877 pg/mL) and high TGF-beta (> 4877 pg/mL). We compared the 2 
      groups in terms of brain natriuretic peptide (BNP), echocardiographic parameters, 
      and clinical outcomes including myocardial infarction, arrhythmias, implantable 
      cardioverter-defibrillator implantation, hospitalization, New York Heart 
      Association (NYHA) class, acute heart failure, and mortality. RESULTS: The HCM 
      patients had higher TGF-beta levels than those in the control group (P = 0.005). In 
      the follow-up, those in the high TGF-beta group had higher BNP levels, larger 
      left-atrial size, thicker interventricular septum, NYHA class, more 
      hospitalizations, and a greater number of clinical adverse events (P < 0.001, P = 
      0.01, P < 0.001, P = 0.002, P < 0.001 and P = 0.003, respectively). TGF-beta level 
      of > 4877 pg/mL can predict adverse events with a specificity of 75% and a 
      sensitivity of 72% (P = 0.014). In multivariate regression analysis, TGF-beta, BNP, 
      and interventricular septum thickness were significantly associated with adverse 
      events (P = 0.028, P = 0.030, and P = 0.034, respectively). CONCLUSIONS: The 
      TGF-beta level is higher in HCM patients and associated with a poor prognosis in 
      HCM.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Ayca, Burak
AU  - Ayca B
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Sahin, Irfan
AU  - Sahin I
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Kucuk, Suat Hayri
AU  - Kucuk SH
AD  - Department of Biochemistry, Bagcilar Education and Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Akin, Fatih
AU  - Akin F
AD  - Medical Faculty, Department of Cardiology, Mugla Sitki Kocman University, Mugla, 
      Turkey.
FAU - Kafadar, Didem
AU  - Kafadar D
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Avsar, Murat
AU  - Avsar M
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Avci, Ilker Ilhan
AU  - Avci II
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Gungor, Baris
AU  - Gungor B
AD  - Department of Cardiology, Siyami Ersek Education and Research Hospital, Istanbul, 
      Turkey.
FAU - Okuyan, Ertugrul
AU  - Okuyan E
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
FAU - Dinckal, Mustafa Hakan
AU  - Dinckal MH
AD  - Department of Cardiology, Bagcilar Education Research Hospital, Bagcilar, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150514
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Transforming Growth Factor beta1)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/*blood/diagnostic imaging/mortality
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Prognosis
MH  - Transforming Growth Factor beta1/*blood
MH  - Ultrasonography
MH  - Young Adult
PMC - PMC6711023
EDAT- 2015/05/15 06:00
MHDA- 2016/03/24 06:00
PMCR- 2015/05/14
CRDT- 2015/05/15 06:00
PHST- 2014/12/21 00:00 [received]
PHST- 2015/02/12 00:00 [revised]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/05/15 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2016/03/24 06:00 [medline]
PHST- 2015/05/14 00:00 [pmc-release]
AID - CLC22404 [pii]
AID - 10.1002/clc.22404 [doi]
PST - ppublish
SO  - Clin Cardiol. 2015 Jun;38(6):371-7. doi: 10.1002/clc.22404. Epub 2015 May 14.