PMID- 25973783
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 182
DP  - 2015 Aug 15
TI  - Correlations between amygdala volumes and serum levels of BDNF and NGF as a 
      neurobiological markerin adolescents with bipolar disorder.
PG  - 50-6
LID - S0165-0327(15)00231-1 [pii]
LID - 10.1016/j.jad.2015.04.016 [doi]
AB  - BACKGROUND: The amygdala is repeatedly implicated as a critical component of the 
      neurocircuitry regulating emotional valence. Studies have frequently reported 
      reduced amygdala volumes in children and adolescents with bipolar disorder (BD). 
      Brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play 
      critical roles in growth, differentiation, maintenance, and synaptic plasticity 
      of neuronal systems in adolescent brain development. The aim of the present study 
      was to assess amygdala volumesand its correlation with serum levels of NGF and 
      BDNF in euthymic adolescents with BD and healthy controls. METHODS: Using 
      structural MRI, we compared the amygdala volumes of 30 euthymic subjects with BD 
      with 23 healthy control subjects aged between 13 and 19 years during a 
      naturalistic clinical follow-up. The boundaries of the amygdala were outlined 
      manually. Serum BDNF and NGF levels were measured using sandwich-ELISA and 
      compared between the study groups. RESULTS: The right or left amygdala volume did 
      not differ between the study groups.The right and left amygdala volumes were 
      highly correlated with levels of BDNF in the combined BD group and the 
      valproate-treated group.Both R and L amygdala volumes were correlated with BDNF 
      levels in healthy controls. The left amygdala volumes were correlated with BDNF 
      levels in the lithium-treated group. LIMITATIONS: This cross-sectional study 
      cannot inform longitudinal changes in brain structure. Further studies with 
      larger sample sizes are needed to improve reliability. CONCLUSIONS: The 
      correlations between amygdala volumes and BDNF levels might be an early 
      neuromarker for diagnosis and/or treatment response in adolescents with BD.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Inal-Emiroglu, F Neslihan
AU  - Inal-Emiroglu FN
AD  - Dokuz Eylul University Medical School, Child and Adolescent Psychiatry 
      Department, Izmir, Turkey. Electronic address: neslihan.emiroglu@deu.edu.tr.
FAU - Karabay, Nuri
AU  - Karabay N
AD  - Dokuz Eylul University Medical School, Radiology Department, Izmir, Turkey.
FAU - Resmi, Halil
AU  - Resmi H
AD  - Dokuz Eylul University Medical School, Medical Biochemistry Department, Izmir, 
      Turkey.
FAU - Guleryuz, Handan
AU  - Guleryuz H
AD  - Dokuz Eylul University Medical School, Radiology Department, Izmir, Turkey.
FAU - Baykara, Burak
AU  - Baykara B
AD  - Dokuz Eylul University Medical School, Child and Adolescent Psychiatry 
      Department, Izmir, Turkey.
FAU - Alsen, Sevay
AU  - Alsen S
AD  - Behcet Uz Children Hospital, Izmir, Turkey.
FAU - Senturk-Pilan, Birsen
AU  - Senturk-Pilan B
AD  - Manisa Mental Health Hospital, Manisa, Turkey.
FAU - Akay, Aynur
AU  - Akay A
AD  - Dokuz Eylul University Medical School, Child and Adolescent Psychiatry 
      Department, Izmir, Turkey.
FAU - Kose, Samet
AU  - Kose S
AD  - University of Texas Medical School at Houston, Department of Psychiatry and 
      Behavioral Sciences and Center for Neurobehavioral Research on Addiction (CNRA), 
      Houston, TX, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150418
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amygdala/*pathology
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood/diagnosis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Growth Factor/*blood
MH  - Organ Size
MH  - Reproducibility of Results
MH  - Valproic Acid/therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - Adolescents
OT  - Amygdala volumes
OT  - BDNF
OT  - Bipolar disorder
OT  - NGF
EDAT- 2015/05/15 06:00
MHDA- 2015/12/29 06:00
CRDT- 2015/05/15 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2015/02/10 00:00 [revised]
PHST- 2015/04/08 00:00 [accepted]
PHST- 2015/05/15 06:00 [entrez]
PHST- 2015/05/15 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - S0165-0327(15)00231-1 [pii]
AID - 10.1016/j.jad.2015.04.016 [doi]
PST - ppublish
SO  - J Affect Disord. 2015 Aug 15;182:50-6. doi: 10.1016/j.jad.2015.04.016. Epub 2015 
      Apr 18.