PMID- 25974999
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20191113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 61
IP  - 3-4
DP  - 2015
TI  - Soluble receptor of advanced glycation end-products in patients with acute 
      myocardial infarction treated with remote ischaemic conditioning.
PG  - 323-8
AB  - BACKGROUND: Several studies have demonstrated that soluble receptor of advanced 
      glycation end-products (sRAGE) is a valuable inflammatory biomarker in 
      cardiovascular disease (CVD). Remote ischaemic conditioning may rescue myocardial 
      tissue during acute myocardial infarction (AMI). In the present study, we 
      evaluate whether sRAGE is a helpful biomarker in patients with AMI receiving 
      remote ischaemic conditioning. METHODS: Plasma sRAGE levels were measured in 191 
      patients with ST-elevation myocardial infarction (STEMI) treated with primary 
      percutaneous intervention (pPCI) of which 97 patients were randomised to receive 
      remote ischaemic conditioning. RESULTS: The sRAGE levels were not different when 
      compared to the randomised controls. In 122 patients, measurement of myocardial 
      salvage index (SI) was obtained. Patients who received remote ischaemic 
      conditioning had significantly higher SI compared to the controls (p < 0.03), 
      although this effect was not seen in sRAGE concentrations. However, sRAGE levels 
      increased with higher New York Heart Association (NYHA) classification after 30 
      days of follow-up. CONCLUSIONS: sRAGE levels do not reflect increased SI in AMI 
      patients who received remote ischaemic conditioning prior to hospital admission.
FAU - Jensen, Louise Jung Norgaard
AU  - Jensen LJ
FAU - Munk, Kim
AU  - Munk K
FAU - Flyvbjerg, Allan
AU  - Flyvbjerg A
FAU - Botker, Hans Erik
AU  - Botker HE
FAU - Bjerre, Mette
AU  - Bjerre M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Aged
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/blood
MH  - Clinical Laboratory Techniques
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Ischemia/*pathology
MH  - Ischemic Preconditioning
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Prospective Studies
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
EDAT- 2015/05/16 06:00
MHDA- 2015/06/10 06:00
CRDT- 2015/05/16 06:00
PHST- 2015/05/16 06:00 [entrez]
PHST- 2015/05/16 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - 10.7754/clin.lab.2014.140913 [doi]
PST - ppublish
SO  - Clin Lab. 2015;61(3-4):323-8. doi: 10.7754/clin.lab.2014.140913.
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