PMID- 2597507
OWN - NLM
STAT- MEDLINE
DCOM- 19900206
LR  - 20161021
IS  - 0889-7190 (Print)
IS  - 0889-7190 (Linking)
VI  - 35
IP  - 3
DP  - 1989 Jul-Sep
TI  - Myocardial oxygen consumption. Comparison between left atrial pulsatile 
      synchronous and asynchronous bypass.
PG  - 461-3
AB  - This controlled study was undertaken to quantitate the effect of R-wave 
      synchronization (counterpulsation) on myocardial oxygen consumption (MVO2) as 
      reflected by the tension time index (TTI) during pulsatile left atrial to aortic 
      bypass. Pulsatile ventricular assist devices were implanted in eight 
      anesthetized, fully hemodynamically instrumented animals. After baseline 
      measurement of TTI, heart rate, cardiac output, mean aortic and left atrial 
      pressures, pulsatile left atrial to aortic bypass was instituted. Measurements 
      were then continuously recorded during both left atrial pulsatile synchronous 
      (LAPS) and asynchronous (LAPAS) bypass periods of pumping. Heart rate and mean 
      aortic pressure were controlled throughout the experiment. TTI = 1819 +/- 95 
      mmHg-sec (control); 987 +/- 127 mmHg-sec (LAPAS); and 763 +/- 89 mmHg-sec (LAPS). 
      The results indicate TTI, and therefore MVO2, is reduced significantly from 
      control levels by either LAPS or LAPAS bypass. However, R-wave synchronization 
      (counterpulsation) offers no further benefit in reducing TTI over the less 
      complex LAPAS or full-to-empty mode pumping.
FAU - Davis, P K
AU  - Davis PK
AD  - College of Medicine, Division of Artificial Organs, Pennsylvania State 
      University, Hershey 17033.
FAU - Pae, W E Jr
AU  - Pae WE Jr
FAU - Miller, C A
AU  - Miller CA
FAU - Parascandola, S A
AU  - Parascandola SA
LA  - eng
GR  - 5R29/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - ASAIO Trans
JT  - ASAIO transactions
JID - 8611947
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Counterpulsation/*instrumentation
MH  - Electrocardiography
MH  - Heart Atria/*physiopathology
MH  - Heart Ventricles/physiopathology
MH  - *Heart-Assist Devices
MH  - Myocardium/*metabolism
MH  - Oxygen Consumption/*physiology
MH  - Shock, Cardiogenic/physiopathology
EDAT- 1989/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
PST - ppublish
SO  - ASAIO Trans. 1989 Jul-Sep;35(3):461-3.