PMID- 25976439
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20181113
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 36
IP  - 3
DP  - 2015 May-Jun
TI  - Selective IgE deficiency and cardiovascular diseases.
PG  - 225-9
LID - 10.2500/aap.2015.36.3825 [doi]
AB  - Selective immunoglobulin E (IgE) deficiency (IgED) is defined as serum levels of 
      IgE more than or equal to 2 kIU/L and is associated with immune dysregulation and 
      autoimmunity. This study aimed to investigate a prevalence of atherosclerotic 
      cardiovascular disease (ASCVD) in population with IgED. Within the electronic 
      patient record (EPR) database of Leumit Health Care Services (LHS) in Israel, 
      data capture was performed using IBM Cognos 10.1.1 BI Report Studio software. The 
      case samples were drawn from the full study population (n = 18,487), having any 
      allergy-related symptoms and/or those requesting antiallergy medications and 
      performed serum total IgE measurement during 2012 at LHS. All subjects aged more 
      than or equal to 40 years old, with serum total IgE less than 2 kIU/L were 
      included in case group. Control group was randomly sampled from the remained 
      subjects, with a case-control ratio of 10 controls for each case (1:10). The 
      comorbid cardiovascular diseases during less than or equal to 10 years before 
      serum total IgE testing were identified and retrieved using specific 
      International Classification of Diseases, 9th Revision, Clinical Modification 
      diagnostic codes. There were 103 in case and 1030 subjects in control group. 
      Compared with control group patients, the case group had significantly more 
      arterial hypertension [34 (37.7%) versus 187 (18.2%), p < 0.001], ischemic heart 
      disease (IHD) [26 (25.2%) versus 87 (8.4%), p < 0.001], carotid stenosis [5 
      (4.9%) versus 7 (0.7%), p = 0.003], cerebrovascular disease (CVD) [3 (2.9%) 
      versus 5 (0.5%), p = 0.029], and peripheral vascular disease (PVD) [4 (3.9%) 
      versus 9 (0.9%), p = 0.024]. IgED is associated with higher prevalence of 
      arterial hypertension and ASCVD.
FAU - Magen, Eli
AU  - Magen E
AD  - Leumit Health Services, Barzilai Medical Center, Ben-Gurion University of Negev, 
      Ashkelon, Israel.
FAU - Mishal, Joseph
AU  - Mishal J
FAU - Vardy, Daniel
AU  - Vardy D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/*epidemiology/*etiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual
MH  - Dysgammaglobulinemia/blood/*complications
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/*deficiency
MH  - Israel/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
PMC - PMC4405604
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2015/05/16 06:00
MHDA- 2016/02/04 06:00
PMCR- 2015/05/01
CRDT- 2015/05/16 06:00
PHST- 2015/05/16 06:00 [entrez]
PHST- 2015/05/16 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - AAP232-14 [pii]
AID - 10.2500/aap.2015.36.3825 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2015 May-Jun;36(3):225-9. doi: 10.2500/aap.2015.36.3825.