PMID- 25976476
OWN - NLM
STAT- MEDLINE
DCOM- 20151103
LR  - 20181113
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 467
IP  - 2
DP  - 2015 Aug
TI  - Papillary-cystic pattern is characteristic in mammary analogue secretory 
      carcinomas but is rarely observed in acinic cell carcinomas of the salivary 
      gland.
PG  - 145-53
LID - 10.1007/s00428-015-1786-8 [doi]
AB  - Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 
      translocation and morphologically overlaps with acinic cell carcinoma (AciCC). 
      Before the recognition of MASC, in AciCC, four histologic patterns were 
      identified including microcystic, solid, papillary-cystic, and follicular. The 
      aim of this study was to evaluate histologic patterns in these two neoplasms 
      through comprehensive histologic subtyping. Using fluorescence in situ 
      hybridization (FISH), we identified 14 cases of MASC and 21 cases of AciCC. We 
      used comprehensive histologic subtyping to provide a semiquantitive assessment of 
      histologic patterns in each tumor and performed immunohistochemical analyses 
      including S100/vimentin/mammaglobin/DOG1. MASC often presented papillary-cystic 
      patterns without a solid component, previously considered to be one of the four 
      major patterns associated with AciCC. However, in our study, this histologic 
      feature was rarely seen in AciCC and more characteristic of MASC. In aspiration 
      cytology samples, MASC was associated with more cellular atypia. An 
      immunohistochemical panel of S100/mammaglobin/DOG1 was found useful for 
      differential diagnosis. Comprehensive subtyping of histologic patterns is a 
      useful screening method prior to initiation of molecular testing.
FAU - Hsieh, Min-Shu
AU  - Hsieh MS
AD  - Department of Pathology, National Taiwan University Hospital and National Taiwan 
      University College of Medicine, No 7, Chung-Shan South Road, 100, Taipei, Taiwan.
FAU - Chou, Yueh-Hung
AU  - Chou YH
FAU - Yeh, Shin-Joe
AU  - Yeh SJ
FAU - Chang, Yih-Leong
AU  - Chang YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150515
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ETV6-NTRK3 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Acinar Cell/genetics/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/genetics
MH  - Polymerase Chain Reaction
MH  - Salivary Gland Neoplasms/genetics/metabolism/*pathology
MH  - Young Adult
EDAT- 2015/05/16 06:00
MHDA- 2015/11/04 06:00
CRDT- 2015/05/16 06:00
PHST- 2014/12/05 00:00 [received]
PHST- 2015/05/06 00:00 [accepted]
PHST- 2015/02/25 00:00 [revised]
PHST- 2015/05/16 06:00 [entrez]
PHST- 2015/05/16 06:00 [pubmed]
PHST- 2015/11/04 06:00 [medline]
AID - 10.1007/s00428-015-1786-8 [doi]
PST - ppublish
SO  - Virchows Arch. 2015 Aug;467(2):145-53. doi: 10.1007/s00428-015-1786-8. Epub 2015 
      May 15.