PMID- 25977069
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20150803
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 48
IP  - 12
DP  - 2015 Aug
TI  - GlycA, a biomarker of inflammatory glycoproteins, is more closely related to the 
      leptin/adiponectin ratio than to glucose tolerance status.
PG  - 811-4
LID - S0009-9120(15)00169-1 [pii]
LID - 10.1016/j.clinbiochem.2015.05.001 [doi]
AB  - OBJECTIVES: Plasma GlycA is a recently developed biomarker whose nuclear magnetic 
      resonance signal originates from glycosylated acute-phase proteins. The aim of 
      our study was to determine potential relationships between GlycA and adiposity, 
      insulin resistance (HOMA(ir)), high sensitive C-reactive protein (hs-CRP), 
      leptin, adiponectin, and the leptin/adiponectin ratio, and to test whether GlycA 
      is elevated in subjects with impaired fasting glucose (IFG) and type 2 diabetes 
      mellitus (T2DM). DESIGN AND METHODS: Plasma GlycA, hs-CRP, leptin, adiponectin, 
      the leptin/adiponectin ratio, and insulin resistance (HOMA(ir)) were measured in 
      103 fasting subjects (30 with normal fasting glucose, 25 with IFG and 48 with 
      T2DM). RESULTS: In all subjects combined, plasma GlycA was correlated positively 
      with body mass index (BMI), HOMA(ir), hs-CRP, leptin and the leptin/adiponectin 
      ratio, and inversely with adiponectin (p < 0.05 to p < 0.001). GlycA did not 
      significantly vary according to glucose tolerance category (p = 0.060). GlycA was 
      related positively to the leptin/adiponectin ratio (p = 0.049), independent of 
      BMI (p = 0.056) and HOMA(ir) (p = 0.50). CONCLUSIONS: High plasma GlycA reflects 
      a pro-inflammatory state. Adipose tissue-associated inflammatory processes could 
      contribute to increased circulating levels of glycosylated acute-phase proteins.
CI  - Copyright (c) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Dullaart, Robin P F
AU  - Dullaart RP
AD  - Department of Endocrinology, University of Groningen, University Medical Center 
      Groningen, Groningen, The Netherlands. Electronic address: 
      r.p.f.dullaart@int.umcg.nl.
FAU - Gruppen, Eke G
AU  - Gruppen EG
AD  - Department of Endocrinology, University of Groningen, University Medical Center 
      Groningen, Groningen, The Netherlands; Department of Nephrology, University of 
      Groningen, University Medical Center Groningen, Groningen, The Netherlands.
FAU - Connelly, Margery A
AU  - Connelly MA
AD  - LabCorp, Raleigh, NC, USA.
FAU - Otvos, James D
AU  - Otvos JD
AD  - LabCorp, Raleigh, NC, USA.
FAU - Lefrandt, Joop D
AU  - Lefrandt JD
AD  - Department of Vascular Medicine, University of Groningen, University Medical 
      Center Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20150511
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycoproteins)
RN  - 0 (Leptin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycoproteins/*blood
MH  - Glycosylation
MH  - Humans
MH  - Inflammation/blood
MH  - Leptin/*blood
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Nuclear Magnetic Resonance, Biomolecular
OTO - NOTNLM
OT  - C-reactive protein
OT  - Diabetes mellitus
OT  - Glycoproteins
OT  - Leptin/adiponectin ratio
OT  - Nuclear magnetic resonance spectroscopy
EDAT- 2015/05/16 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/05/16 06:00
PHST- 2015/03/27 00:00 [received]
PHST- 2015/05/01 00:00 [revised]
PHST- 2015/05/02 00:00 [accepted]
PHST- 2015/05/16 06:00 [entrez]
PHST- 2015/05/16 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - S0009-9120(15)00169-1 [pii]
AID - 10.1016/j.clinbiochem.2015.05.001 [doi]
PST - ppublish
SO  - Clin Biochem. 2015 Aug;48(12):811-4. doi: 10.1016/j.clinbiochem.2015.05.001. Epub 
      2015 May 11.