PMID- 25981175
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20150716
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 27
IP  - 8
DP  - 2015 Aug
TI  - Neonatal Treatment with a Pegylated Leptin Antagonist Induces Sexually Dimorphic 
      Effects on Neurones and Glial Cells, and on Markers of Synaptic Plasticity in the 
      Developing Rat Hippocampal Formation.
PG  - 658-69
LID - 10.1111/jne.12294 [doi]
AB  - The present study aimed to better understand the role of the neonatal leptin 
      surge, which peaks on postnatal day (PND)9-10, on the development of the 
      hippocampal formation. Accordingly, male and female rats were administered with a 
      pegylated leptin antagonist on PND9 and the expression of neurones, glial cells 
      and diverse markers of synaptic plasticity was then analysed by 
      immunohistochemistry in the hippocampal formation. Antagonism of the actions of 
      leptin at this specific postnatal stage altered the number of glial fibrillary 
      acidic protein positive cells, and also affected type 1 cannabinoid receptors, 
      synaptophysin and brain-derived neurotrophic factor (BDNF), with the latter 
      effect being sexually dimorphic. The results indicate that the physiological 
      leptin surge occurring around PND 9-10 is critical for hippocampal formation 
      development and that the dynamics of leptin activity might be different in males 
      and females. The data obtained also suggest that some but not all the previously 
      reported effects of maternal deprivation on hippocampal formation development 
      (which markedly reduces leptin levels at PND 9-10) might be mediated by leptin 
      deficiency in these animals.
CI  - (c) 2015 British Society for Neuroendocrinology.
FAU - Lopez-Gallardo, M
AU  - Lopez-Gallardo M
AD  - Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, 
      Spain.
FAU - Anton-Fernandez, A
AU  - Anton-Fernandez A
AD  - Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, 
      Spain.
FAU - Llorente, R
AU  - Llorente R
AD  - Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad 
      Complutense, Madrid, Spain.
FAU - Mela, V
AU  - Mela V
AD  - Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad 
      Complutense, Madrid, Spain.
FAU - Llorente-Berzal, A
AU  - Llorente-Berzal A
AD  - Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad 
      Complutense, Madrid, Spain.
FAU - Prada, C
AU  - Prada C
AD  - Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, 
      Spain.
FAU - Viveros, M P
AU  - Viveros MP
AD  - Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad 
      Complutense, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Leptin)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 0 (Synaptophysin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Biomarkers/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects/growth & development/metabolism
MH  - Leptin/*antagonists & inhibitors/physiology
MH  - Male
MH  - Neuroglia/*metabolism
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Neurons/*metabolism
MH  - Rats
MH  - Receptor, Cannabinoid, CB1/metabolism
MH  - *Sex Characteristics
MH  - Synaptophysin/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - astrocytes
OT  - cannabinoid receptors
OT  - developing hippocampus
OT  - neonatal leptin
OT  - synaptophysin
EDAT- 2015/05/20 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/05/19 06:00
PHST- 2015/12/03 00:00 [received]
PHST- 2015/04/04 00:00 [revised]
PHST- 2015/04/11 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1111/jne.12294 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2015 Aug;27(8):658-69. doi: 10.1111/jne.12294.