PMID- 25981868
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20181202
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 66
IP  - 6
DP  - 2015 Dec
TI  - Endogenous contrast T1rho cardiac magnetic resonance for myocardial fibrosis in 
      hypertrophic cardiomyopathy patients.
PG  - 520-6
LID - S0914-5087(15)00090-8 [pii]
LID - 10.1016/j.jjcc.2015.03.005 [doi]
AB  - BACKGROUND: Late gadolinium enhancement (LGE) is a standard method to evaluate 
      myocardial fibrosis, but restricted due to contrast agent contraindications. 
      Non-contrast T1rho can generate endogenous contrast, and detect fibrosis in 
      chronic myocardial infarction. However, T1rho for hypertrophic cardiomyopathy 
      (HCM) patients is still unreported. The present study aimed to investigate T1rho 
      for fibrotic assessment and the clinical implication in HCM patients. METHODS: 18 
      HCM patients and 8 controls underwent T1rho, cine, and LGE cardiac magnetic 
      resonance (CMR). T1rho relaxation time maps were created. Left ventricular (LV) 
      parameters assessed included wall thickness, wall thickening, chamber volumes, 
      ejection function, and fibrotic size. New York Heart Association (NYHA) 
      functional classification was conducted. RESULTS: Hyper-T1rho value was 
      identified in 12 HCM patients, consistent with LGE. The mean T1rho values of 
      controls, LGE-negative patients, and remote myocardium of LGE-positive patients 
      were 42.2+/-1.6ms, 43.9+/-2.5ms, and 42.5+/-1.2ms respectively, and these values showed 
      no significant difference (all p>0.05). T1rho-3-SD and T1rho-4-SD fibrotic sizes 
      (32.5+/-14.0% and 25.1+/-11.5%) did not differ from LGE fibrotic size (28.1+/-11.2%) 
      (both p>0.05). For the fibrotic size, T1rho-3-SD method obtained the strongest 
      correlation with LGE (r=0.88, p<0.001), and T1rho-4-SD obtained the minimal mean 
      difference with LGE (-3.1%; -15.2 to 9.1%), compared with other SDs. All the 
      fibrotic sizes assessed by both methods correlated directly with LV maximal 
      end-diastolic thickness (all p<0.05). Negative correlation was found between 
      T1rho-4-SD fibrotic size and LV ejection fraction (r=-0.49, p=0.11). T1rho-4-SD 
      fibrotic size showed positive correlation with NYHA class (r=0.46, p=0.13). 
      CONCLUSIONS: T1rho CMR has potential to detect fibrosis in HCM patients. 4-SD may 
      be the appropriate threshold for assessment.
CI  - Copyright (c) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Wang, Chunhua
AU  - Wang C
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Mallinckrodt Institute of Radiology, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Wang, Yuqing
AU  - Wang Y
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; 
      CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, 
      National Center for Nanoscience and Technology of China, Beijing, China.
FAU - Xia, Rui
AU  - Xia R
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; 
      Department of Radiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Yin, Qian
AU  - Yin Q
AD  - Mallinckrodt Institute of Radiology, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Xu, Ziqian
AU  - Xu Z
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Liao, Jichun
AU  - Liao J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; 
      Department of Radiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhang, Bing
AU  - Zhang B
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Gao, Fabao
AU  - Gao F
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China. 
      Electronic address: gaofabao@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150514
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Contrast Media)
RN  - 0 (Mitochondrial Proteins)
RN  - EC 3.6.1.- (RHOT1 protein, human)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*complications
MH  - *Contrast Media
MH  - Epicardial Mapping
MH  - Female
MH  - Fibrosis/diagnosis
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Mitochondrial Proteins/*analysis
MH  - Myocardial Infarction/pathology
MH  - Myocardium/*pathology
MH  - Ventricular Function, Left
MH  - rho GTP-Binding Proteins/*analysis
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Endogenous contrast
OT  - Hypertrophic cardiomyopathy
OT  - Myocardial fibrosis
OT  - T1rho
EDAT- 2015/05/20 06:00
MHDA- 2016/06/21 06:00
CRDT- 2015/05/19 06:00
PHST- 2014/10/07 00:00 [received]
PHST- 2015/02/16 00:00 [revised]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
AID - S0914-5087(15)00090-8 [pii]
AID - 10.1016/j.jjcc.2015.03.005 [doi]
PST - ppublish
SO  - J Cardiol. 2015 Dec;66(6):520-6. doi: 10.1016/j.jjcc.2015.03.005. Epub 2015 May 
      14.