PMID- 25982069
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20181202
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Linking)
VI  - 61
DP  - 2015 Aug
TI  - Examining the levels of BDNF and cortisol in children and adolescent victims of 
      sexual abuse--a preliminary study.
PG  - 23-7
LID - S0010-440X(15)00064-4 [pii]
LID - 10.1016/j.comppsych.2015.04.013 [doi]
AB  - BACKGROUND: Previous reports have suggested the biological and psychological 
      effects of trauma induced by cortisol and brain-derived neurotrophic factor 
      (BDNF). The present study compared the levels of BDNF, cortisol, and 
      adrenocorticotropic hormone (ACTH) in children and adolescent victims of sexual 
      abuse to those without a trauma history. METHODS: The study was conducted in the 
      Department of Child Psychiatry at Dicle University. The study included 44 
      children (M/F: 12/32) aged between 8 and 17years who experienced sexual abuse 
      with 42 age-and gender-matched children who did not have a history of trauma. 
      Cortisol, ACTH, and BDNF levels were measured using ELISA. RESULTS: Cortisol 
      levels were higher and BDNF levels were significantly lower in the victims of 
      sexual abuse compared to the control group. The mean time that elapsed from the 
      initial sexual abuse occurrence until the date of examination was 
      22.7+/-21.7months. The evaluation of the relationship between this time span and 
      cortisol levels revealed that cortisol levels decreased with increasing time 
      after trauma. Cortisol and BDNF levels were lower in the victims who experienced 
      multiple sexual assaults. CONCLUSIONS: The results of the present study suggest 
      that cortisol and BDNF could be biological molecular mediators of the effects of 
      trauma on biological and psychological systems. This is the first report on the 
      effects of cortisol and BDNF induced trauma in child and adolescent victims of 
      sexual abuse.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Simsek, Seref
AU  - Simsek S
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: drserefsimsek@gmail.com.
FAU - Yuksel, Tugba
AU  - Yuksel T
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: tyuksel44@yahoo.com.
FAU - Kaplan, Ibrahim
AU  - Kaplan I
AD  - Dicle University, Medical School, Department of Biochemistry, Diyarbakir, Turkey. 
      Electronic address: dribrahimkaplan@hotmail.com.
FAU - Uysal, Cem
AU  - Uysal C
AD  - Dicle University, Medical, School Department of Forensic Medicine, Diyarbakir, 
      Turkey. Electronic address: drcemuysal@gmail.com.
FAU - Alaca, Rumeysa
AU  - Alaca R
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: rumeysaalaca17@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150511
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adrenocorticotropic Hormone/*blood
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - *Child Abuse, Sexual
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Male
EDAT- 2015/05/20 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/05/19 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/04/27 00:00 [revised]
PHST- 2015/04/29 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0010-440X(15)00064-4 [pii]
AID - 10.1016/j.comppsych.2015.04.013 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2015 Aug;61:23-7. doi: 10.1016/j.comppsych.2015.04.013. Epub 
      2015 May 11.