PMID- 25982109
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20181202
IS  - 2213-1787 (Electronic)
IS  - 2213-1779 (Linking)
VI  - 3
IP  - 6
DP  - 2015 Jun
TI  - Does Age Influence Cardiac Resynchronization Therapy Use and Outcome?
PG  - 497-504
LID - S2213-1779(15)00156-0 [pii]
LID - 10.1016/j.jchf.2015.01.012 [doi]
AB  - OBJECTIVES: This study sought to describe the use of CRT-D and its association 
      with survival for older patients. BACKGROUND: Many patients who receive cardiac 
      resynchronization therapy with defibrillator (CRT-D) in practice are older than 
      those included in clinical trials. METHODS: We identified patients undergoing ICD 
      implantation in the National Cardiovascular Disease Registry (NCDR) ICD registry 
      from 2006 to 2009, who also met clinical trial criteria for CRT, including left 
      ventricular ejection fraction (LVEF) </=35%, QRS >/=120 ms, and New York Heart 
      Association (NYHA) functional class III or IV. NCDR registry data were linked to 
      the social security death index to determine the primary outcome of time to death 
      from any cause. We identified 70,854 patients from 1,187 facilities who met prior 
      trial criteria for CRT-D. The mean age of the 58,147 patients receiving CRT-D was 
      69.4 years with 6.4% of patients age 85 or older. CRT use was 80% or higher among 
      candidates in all age groups. Follow-up was available for 42,285 patients age >/=65 
      years at 12 months. RESULTS: Receipt of CRT-D was associated with better survival 
      at 1 year (82.1% vs. 77.1%, respectively) and 4 years (54.0% vs. 46.2% , 
      respectively) than in those receiving only an ICD (p < 0.001). The CRT 
      association with improved survival was not different for different age groups 
      (p = 0.86 for interaction). CONCLUSIONS: More than 80% of older patients 
      undergoing ICD implantation who were candidates for a CRT-D received the combined 
      device. Mortality in older patients undergoing ICD implantation was high but was 
      lower for those receiving CRT-D.
CI  - Copyright (c) 2015 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Heidenreich, Paul A
AU  - Heidenreich PA
AD  - Veterans Administration Palo Alto Healthcare System, Palo Alto, California. 
      Electronic address: heiden@standford.edu.
FAU - Tsai, Vivian
AU  - Tsai V
AD  - Palo Alto Medical Foundation, Palo Alto, California.
FAU - Bao, Haikun
AU  - Bao H
AD  - Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
FAU - Curtis, Jeptha
AU  - Curtis J
AD  - Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
FAU - Goldstein, Mary
AU  - Goldstein M
AD  - Veterans Administration Palo Alto Healthcare System, Palo Alto, California.
FAU - Curtis, Lesley
AU  - Curtis L
AD  - Duke Clinical Research Institute, Durham, North Carolina.
FAU - Hernandez, Adrian
AU  - Hernandez A
AD  - Duke Clinical Research Institute, Durham, North Carolina.
FAU - Peterson, Pamela
AU  - Peterson P
AD  - University of Colorado Anschutz Medical Campus, Aurora, Colorado.
FAU - Turakhia, Mintu P
AU  - Turakhia MP
AD  - Veterans Administration Palo Alto Healthcare System, Palo Alto, California.
FAU - Masoudi, Frederick A
AU  - Masoudi FA
AD  - University of Colorado Anschutz Medical Campus, Aurora, Colorado.
LA  - eng
GR  - K08 HS019814-01/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150514
PL  - United States
TA  - JACC Heart Fail
JT  - JACC. Heart failure
JID - 101598241
SB  - IM
CIN - JACC Heart Fail. 2015 Jun;3(6):505-7. PMID: 25982106
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Resynchronization Therapy/mortality/*statistics & numerical data
MH  - Defibrillators, Implantable/statistics & numerical data
MH  - Female
MH  - Heart Failure/mortality/therapy
MH  - Hospitals/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Registries
MH  - Survival Analysis
MH  - United States/epidemiology
OTO - NOTNLM
OT  - cardiac resynchronization therapy
OT  - elderly
OT  - heart failure
EDAT- 2015/05/20 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/05/19 06:00
PHST- 2014/09/22 00:00 [received]
PHST- 2015/01/01 00:00 [revised]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - S2213-1779(15)00156-0 [pii]
AID - 10.1016/j.jchf.2015.01.012 [doi]
PST - ppublish
SO  - JACC Heart Fail. 2015 Jun;3(6):497-504. doi: 10.1016/j.jchf.2015.01.012. Epub 
      2015 May 14.