PMID- 25982266 OWN - NLM STAT- MEDLINE DCOM- 20160307 LR - 20220317 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 49 DP - 2015 Aug TI - Prediction of rhythmic and periodic EEG patterns and seizures on continuous EEG with early epileptiform discharges. PG - 286-9 LID - S1525-5050(15)00213-9 [pii] LID - 10.1016/j.yebeh.2015.04.044 [doi] AB - BACKGROUND: Continuous EEG (cEEG) is necessary to document nonconvulsive seizures (NCS), nonconvulsive status epilepticus (NCSE), as well as rhythmic and periodic EEG patterns of 'ictal-interictal uncertainty' (RPPIIU) including periodic discharges, rhythmic delta activity, and spike-and-wave complexes in neurological intensive care patients. However, cEEG is associated with significant recording and analysis efforts. Therefore, predictors from short-term routine EEG with a reasonably high yield are urgently needed in order to select patients for evaluation with cEEG. OBJECTIVE: The aim of this study was to assess the prognostic significance of early epileptiform discharges (i.e., within the first 30 min of EEG recording) on the following: (1) incidence of ictal EEG patterns and RPPIIU on subsequent cEEG, (2) occurrence of acute convulsive seizures during the ICU stay, and (3) functional outcome after 6 months of follow-up. METHODS: We conducted a separate analysis of the first 30 min and the remaining segments of prospective cEEG recordings according to the ACNS Standardized Critical Care EEG Terminology as well as NCS criteria and review of clinical data of 32 neurological critical care patients. RESULTS: In 17 patients with epileptiform discharges within the first 30 min of EEG (group 1), electrographic seizures were observed in 23.5% (n = 4), rhythmic or periodic EEG patterns of 'ictal-interictal uncertainty' in 64.7% (n = 11), and neither electrographic seizures nor RPPIIU in 11.8% (n = 2). In 15 patients with no epileptiform discharges in the first 30 min of EEG (group 2), no electrographic seizures were recorded on subsequent cEEG, RPPIIU were seen in 26.7% (n = 4), and neither electrographic seizures nor RPPIIU in 73.3% (n = 11). The incidence of EEG patterns on cEEG was significantly different between the two groups (p = 0.008). Patients with early epileptiform discharges developed acute seizures more frequently than patients without early epileptiform discharges (p = 0.009). Finally, functional outcome six months after discharge was significantly worse in patients with early epileptiform discharges (p=0.01). CONCLUSIONS: Epileptiform discharges within the first 30 min of EEG recording are predictive for the occurrence of ictal EEG patterns and for RPPIIU on subsequent cEEG, for acute convulsive seizures during the ICU stay, and for a worse functional outcome after 6 months of follow-up. This article is part of a Special Issue entitled Status Epilepticus. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Koren, J AU - Koren J AD - Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, 2nd Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria. Electronic address: johannes-peter.koren@wienkav.at. FAU - Herta, J AU - Herta J AD - Department of Neurosurgery, Medical University of Vienna, Vienna, Austria. FAU - Draschtak, S AU - Draschtak S AD - 1st Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria. FAU - Potzl, G AU - Potzl G AD - 1st Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria. FAU - Pirker, S AU - Pirker S AD - Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, 2nd Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria. FAU - Furbass, F AU - Furbass F AD - Austrian Institute of Technology GmbH (AIT), Safety & Security Department, Vienna, Austria. FAU - Hartmann, M AU - Hartmann M AD - Austrian Institute of Technology GmbH (AIT), Safety & Security Department, Vienna, Austria. FAU - Kluge, T AU - Kluge T AD - Austrian Institute of Technology GmbH (AIT), Safety & Security Department, Vienna, Austria. FAU - Baumgartner, C AU - Baumgartner C AD - Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, 2nd Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150515 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 SB - IM MH - Critical Care MH - Delta Rhythm/drug effects MH - Electroencephalography/*drug effects MH - Epilepsy/*drug therapy/epidemiology/physiopathology MH - Female MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Prospective Studies MH - Seizures/*drug therapy/epidemiology/physiopathology MH - Status Epilepticus/*drug therapy/epidemiology/physiopathology MH - Treatment Outcome MH - Uncertainty OTO - NOTNLM OT - ACNS Standardized Critical Care EEG Terminology OT - Continuous EEG OT - Early epileptiform discharges OT - Nonconvulsive seizures OT - Rhythmic and periodic EEG patterns of 'ictal-interictal uncertainty' EDAT- 2015/05/20 06:00 MHDA- 2016/03/08 06:00 CRDT- 2015/05/19 06:00 PHST- 2015/04/08 00:00 [received] PHST- 2015/04/19 00:00 [accepted] PHST- 2015/05/19 06:00 [entrez] PHST- 2015/05/20 06:00 [pubmed] PHST- 2016/03/08 06:00 [medline] AID - S1525-5050(15)00213-9 [pii] AID - 10.1016/j.yebeh.2015.04.044 [doi] PST - ppublish SO - Epilepsy Behav. 2015 Aug;49:286-9. doi: 10.1016/j.yebeh.2015.04.044. Epub 2015 May 15.