PMID- 25982551
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20181202
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 60
DP  - 2015 Aug
TI  - Multifunctional gold nanostar-based nanocomposite: Synthesis and application for 
      noninvasive MR-SERS imaging-guided photothermal ablation.
PG  - 31-41
LID - S0142-9612(15)00427-5 [pii]
LID - 10.1016/j.biomaterials.2015.05.004 [doi]
AB  - We report here the design and facile synthesis of multifunctional gold nanostars 
      based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic 
      gold nanostars followed by the conjugation of Gd chelates. The as-synthesized 
      MGSNs possess strong NIR absorbance, SERS signal and enhanced T1-MR imaging 
      capability with excellent dispersivity and uniform size, as well as great 
      photothermal stability and Raman stability under photothermal conditions. 
      Importantly, MGSNs present excellent performance in vivo after their intravenous 
      injection for both MR and SERS imaging and the high efficiency for killing tumor 
      cells through photothermal ablation with NIR irradiation. A combination of the 
      high spatial resolution of MR and the exciting sub-cell-level sensitivity and 
      resolution of SERS can provide comprehensive information about the tumor to 
      achieve the optimized therapeutic outcome. Therefore, MGSNs are of great 
      potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, 
      focused photothermal tumor therapy.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Gao, Yongping
AU  - Gao Y
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China.
FAU - Li, Yongsheng
AU  - Li Y
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China. 
      Electronic address: ysli@ecust.edu.cn.
FAU - Chen, Jianzhuang
AU  - Chen J
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China.
FAU - Zhu, Shaojia
AU  - Zhu S
AD  - State Key Lab of Bioreactor Engineering, East China University of Science and 
      Technology, Shanghai 200237, China.
FAU - Liu, Xiaohang
AU  - Liu X
AD  - Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 
      200032, China.
FAU - Zhou, Liangping
AU  - Zhou L
AD  - Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 
      200032, China.
FAU - Shi, Ping
AU  - Shi P
AD  - State Key Lab of Bioreactor Engineering, East China University of Science and 
      Technology, Shanghai 200237, China.
FAU - Niu, Dechao
AU  - Niu D
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China.
FAU - Gu, Jinlou
AU  - Gu J
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China.
FAU - Shi, Jianlin
AU  - Shi J
AD  - Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine 
      Materials of Ministry of Education, School of Materials Science and Engineering, 
      East China University of Science and Technology, Shanghai 200237, China; Shanghai 
      Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. 
      Electronic address: jlshi@mail.sic.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150514
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Chelating Agents)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organosilicon Compounds)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-57-5 (Gold)
RN  - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Chelating Agents/chemistry/therapeutic use
MH  - Gold/chemistry/*therapeutic use
MH  - Heterocyclic Compounds/chemistry/*therapeutic use
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Mice, Inbred BALB C
MH  - Nanocomposites/chemistry/*therapeutic use/ultrastructure
MH  - Neoplasms/pathology/*therapy
MH  - Organometallic Compounds/chemistry/*therapeutic use
MH  - Organosilicon Compounds/chemistry/*therapeutic use
MH  - Phototherapy/*methods
MH  - Polyethylene Glycols/chemistry/therapeutic use
MH  - Spectrum Analysis, Raman/*methods
OTO - NOTNLM
OT  - Gold
OT  - MRI
OT  - Nanocomposite
OT  - Photothermal therapy
OT  - SERS
EDAT- 2015/05/20 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/05/19 06:00
PHST- 2015/04/22 00:00 [received]
PHST- 2015/05/03 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - S0142-9612(15)00427-5 [pii]
AID - 10.1016/j.biomaterials.2015.05.004 [doi]
PST - ppublish
SO  - Biomaterials. 2015 Aug;60:31-41. doi: 10.1016/j.biomaterials.2015.05.004. Epub 
      2015 May 14.