PMID- 25982824
OWN - NLM
STAT- MEDLINE
DCOM- 20160707
LR  - 20150803
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 21
IP  - 8
DP  - 2015 Aug
TI  - Short-Term Caloric Restriction Suppresses Cardiac Oxidative Stress and 
      Hypertrophy Caused by Chronic Pressure Overload.
PG  - 656-66
LID - S1071-9164(15)00127-X [pii]
LID - 10.1016/j.cardfail.2015.04.016 [doi]
AB  - BACKGROUND: Caloric restriction (CR) prevents senescent changes, in which 
      reactive oxygen species (ROS) have a critical role. Left ventricular (LV) 
      hypertrophy is a risk factor for cardiovascular diseases. We examined whether CR 
      alters cardiac redox state and hypertrophy from chronic pressure overload. 
      METHODS AND RESULTS: Male c57BL6 mice were subjected to ascending aortic 
      constriction (AAC) with ad libitum caloric intake (AL + AAC group) or 40% 
      restricted caloric intake (CR + AAC group). CR was initiated 2 weeks before AAC 
      and was continued for 4 weeks. Two weeks after constriction, AAC increased LV 
      wall thickness, impaired transmitral flow velocity, and augmented myocyte 
      hypertrophy and fibrosis, in association with enhancement of BNP and collagen III 
      expressions in the AL + AAC group. In the AL + AAC group, oxidative stress in 
      cardiac tissue and mitochondria were enhanced, and NADPH oxidase activity and 
      mitochondrial ROS production were elevated. These changes were significantly 
      attenuated in the CR + AAC group. Additionally, in antioxidant systems, 
      myocardial glutathione peroxidase and superoxide dismutase activities were 
      enhanced in the CR + AAC group. CONCLUSIONS: Chronic pressure overload increased 
      cardiac oxidative damage, in association with cardiac hypertrophy and fibrosis. 
      Short-term CR suppressed oxidative stress and improved cardiac function, 
      suggesting that short-term CR could be a useful strategy to prevent pressure 
      overload-induced cardiac injury.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kobara, Miyuki
AU  - Kobara M
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan. Electronic address: 
      kobara@mb.kyoto-phu.ac.jp.
FAU - Furumori-Yukiya, Akiko
AU  - Furumori-Yukiya A
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
FAU - Kitamura, Miho
AU  - Kitamura M
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
FAU - Matsumura, Mihoko
AU  - Matsumura M
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
FAU - Ohigashi, Makoto
AU  - Ohigashi M
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
FAU - Toba, Hiroe
AU  - Toba H
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
FAU - Nakata, Tetsuo
AU  - Nakata T
AD  - Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150514
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Caloric Restriction/*methods
MH  - Cardiomegaly/*physiopathology
MH  - Echocardiography
MH  - Heart Ventricles/*metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - Caloric restriction
OT  - cardiac hypertrophy
OT  - oxidative stress
EDAT- 2015/05/20 06:00
MHDA- 2016/07/09 06:00
CRDT- 2015/05/19 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/03/30 00:00 [revised]
PHST- 2015/04/29 00:00 [accepted]
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/07/09 06:00 [medline]
AID - S1071-9164(15)00127-X [pii]
AID - 10.1016/j.cardfail.2015.04.016 [doi]
PST - ppublish
SO  - J Card Fail. 2015 Aug;21(8):656-66. doi: 10.1016/j.cardfail.2015.04.016. Epub 
      2015 May 14.