PMID- 25984615
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 2448-5667 (Electronic)
IS  - 0443-5117 (Linking)
VI  - 53
IP  - 3
DP  - 2015 May-Jun
TI  - [Relationship between body fat and creatinine clearence in adults with and 
      without diabetes mellitus].
PG  - 302-7
AB  - BACKGROUND: Obesity is a risk factor for renal damage. This study aimed to 
      determine the relationship between body fat percent and creatinine clearance in 
      adult patients with and without type 2 diabetes mellitus (T2DM). METHODS: An 
      observational prospective cross-correlation study was carried out among adults 
      with and without T2DM between 18 and 60 years of age. It was determined the time 
      of evolution with T2DM, as well as fat percentage (FP), body mass index (BMI), 
      creatinine clearance (Cockroft-Gault [CrCCG]), glycemia and 
      micro/macroalbuminuria. The correlation between CrCCG and FP was determined by 
      Spearman's test. RESULTS: 174 subjects were included in this study. Obesity by 
      BMI and FP in subjects with and without T2DM was similar. Of the studied 
      subjects, 12.6 % didn't have kidney damage and 50.7 % had increased risk of renal 
      disease; the frequencies for stages 1-4 of kidney damage were 12.0, 20.1, 4.0 and 
      0.6 %, respectively. Spearman's test showed a direct relationship between FP and 
      CrCCG, higher in diabetics (r = 0.418, p < 0.0001) than in non-diabetics (p = 
      0.327, p < 0.0001). CONCLUSIONS: The FP was correlated directly with the CrCCG in 
      subjects with and without T2DM; therefore, we can conclude that the greater the 
      kidney damage, the smaller the fat porcentage in the study sample.
FAU - Romero-Campos, Sandra
AU  - Romero-Campos S
AD  - Unidad de Investigacion en Enfermedades Renales, Hospital General "Dr. Agustin 
      O Horan", Servicios de Salud de Yucatan, Yucatan, Mexico. 
      marthamedinaescobedo@hotmail.com.
FAU - Viveros-Cortes, Angel
AU  - Viveros-Cortes A
FAU - Medina-Escobedo, Martha
AU  - Medina-Escobedo M
FAU - Sansores-Espana, Delia
AU  - Sansores-Espana D
FAU - Villanueva-Jorge, Salha
AU  - Villanueva-Jorge S
LA  - spa
PT  - Journal Article
PT  - Observational Study
TT  - Relacion entre grasa corporal y depuracion de creatinina en adultos con y sin 
      diabetes mellitus.
PL  - Mexico
TA  - Rev Med Inst Mex Seguro Soc
JT  - Revista medica del Instituto Mexicano del Seguro Social
JID - 101243727
RN  - 0 (Biomarkers)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adiposity/*physiology
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Creatinine/*blood
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/diagnosis/*physiopathology
MH  - Prospective Studies
MH  - Renal Insufficiency/blood/diagnosis/*etiology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Body fat
OT  - Creatinine clearance
OT  - Diabetes mellitus
EDAT- 2015/05/20 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/05/19 06:00
PHST- 2015/05/19 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PST - ppublish
SO  - Rev Med Inst Mex Seguro Soc. 2015 May-Jun;53(3):302-7.