PMID- 25985941
OWN - NLM
STAT- MEDLINE
DCOM- 20160412
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 31
IP  - 6
DP  - 2015 Aug
TI  - Extracellular volume fraction in coronary chronic total occlusion patients.
PG  - 1211-21
LID - 10.1007/s10554-015-0680-4 [doi]
AB  - (1) To assess extracellular volume fraction (ECV) and regional systolic function 
      in patients presenting with coronary chronic total occlusion (CTO) in areas 
      without significant late gadolinium enhancement (LGE), and (2) to investigate the 
      correlation between angiography collateral flow and ECV in territories supplied 
      by CTO vessels. A total of 50 angiographically documented CTO patients and 15 
      age- and sex-matched normal controls were recruited to the study. Myocardial ECV, 
      was calculated in infarcted, global non-infarcted and the entire myocardium 
      respectively. Segmental ECV was calculated from myocardial segments within the 
      perfusion territory of a CTO vessel. The global and regional systolic function 
      was evaluated using ejection fraction and percent systolic thickening. ECVs in 
      global myocardium and global non-infarcted myocardium were significantly elevated 
      in comparison with that in controls (29.1 +/- 4.2% and 26.6 +/- 2.6% vs. 23.3 +/- 2.0%, 
      all P < 0.005). Global ECV significantly correlated with LV ejection fraction (r 
      = -0.56, P < 0.001) and ECV inversely correlated with systolic thickening in 
      global non-infarcted myocardium (r = -0.31, P < 0.05). The lower segmental ECV 
      was associated with the presence of well-developed collaterals (P = 0.004), and 
      multivariate binary logistic analysis demonstrated that mean segmental ECV and 
      course of disease were the independent discriminator of collateral flow with 
      overall diagnostic accuracy of 74.4%. In patients with CTO, ECV is found to be 
      increased beyond that observed with LGE, and correlates with LV regional wall 
      motion abnormality, which appears to reflect diffuse myocardial fibrosis. Mean 
      segmental ECV value, combined with course of disease, may serve as good 
      predictors of collateral flow.
FAU - Chen, Yin Yin
AU  - Chen YY
AD  - Department of Radiology, Zhongshan Hospital, Fudan University, 180#, Fenglin 
      Road, Shanghai, China.
FAU - Zhang, Wei Guo
AU  - Zhang WG
FAU - Yang, Shan
AU  - Yang S
FAU - Yun, Hong
AU  - Yun H
FAU - Deng, Sheng Ming
AU  - Deng SM
FAU - Fu, Cai Xia
AU  - Fu CX
FAU - Zeng, Meng Su
AU  - Zeng MS
FAU - Jin, Hang
AU  - Jin H
FAU - Guo, Liang
AU  - Guo L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150519
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Collateral Circulation
MH  - Contrast Media
MH  - Coronary Angiography
MH  - Coronary Circulation
MH  - Coronary Occlusion/*diagnosis/diagnostic imaging/pathology/physiopathology
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/methods
MH  - Myocardium/pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Stroke Volume
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnosis/diagnostic 
      imaging/pathology/physiopathology
MH  - *Ventricular Function, Left
EDAT- 2015/05/20 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/05/20 06:00
PHST- 2015/02/12 00:00 [received]
PHST- 2015/05/13 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - 10.1007/s10554-015-0680-4 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2015 Aug;31(6):1211-21. doi: 10.1007/s10554-015-0680-4. 
      Epub 2015 May 19.