PMID- 25986259
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 54
IP  - 10
DP  - 2015
TI  - Drug-induced Liver Injury with HHV-6 Reactivation.
PG  - 1219-22
LID - 10.2169/internalmedicine.54.4329 [doi]
AB  - Liver dysfunction was identified in a 16-year-old boy hospitalized with high 
      fever and abdominal pain and fullness. He had received pharmacotherapy for a 
      headache 2 months previously and other drugs for a high fever 4 days prior to 
      being admitted to our hospital. The patient's liver dysfunction was consistent 
      with and fulfilled the criteria for drug induced liver injury, but the laboratory 
      findings showed elevated procalcitonin levels, hyponatremia and leukocytosis. 
      Moreover, we confirmed the presence of human herpesvirus 6 (HHV-6) DNA. The 
      patient exhibited symptoms of high fever and abdominal pain and fullness but no 
      exanthema. The clinical and laboratory findings did not satisfy the criteria for 
      drug-induced hypersensitivity syndrome, and we speculate that the diversity of 
      clinical and laboratory findings may have resulted from HHV-6 reactivation. To 
      the best of our knowledge, this is the first case report on drug-induced liver 
      injury with various findings due to HHV-6 reactivation. HHV-6 reactivation should 
      be considered in patients with drug induced liver injury even in the absence of 
      exanthema.
FAU - Fujita, Masashi
AU  - Fujita M
AD  - Department of Gastroenterology and Rheumatology, Fukushima Medical University 
      School of Medicine, Japan.
FAU - Takahashi, Atsushi
AU  - Takahashi A
FAU - Imaizumi, Hiromichi
AU  - Imaizumi H
FAU - Hayashi, Manabu
AU  - Hayashi M
FAU - Okai, Ken
AU  - Okai K
FAU - Kanno, Yukiko
AU  - Kanno Y
FAU - Abe, Kazumichi
AU  - Abe K
FAU - Watanabe, Hiroshi
AU  - Watanabe H
FAU - Ohira, Hiromasa
AU  - Ohira H
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150515
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
CIN - Intern Med. 2016;55(7):853. PMID: 27041180
MH  - Abdominal Pain/*etiology/pathology/virology
MH  - Adolescent
MH  - Chemical and Drug Induced Liver Injury/*complications/pathology
MH  - Fever/*etiology/pathology/virology
MH  - Herpesvirus 6, Human/isolation & purification/*pathogenicity
MH  - Humans
MH  - Male
MH  - Roseolovirus Infections/*complications/pathology
MH  - *Virus Activation
EDAT- 2015/05/20 06:00
MHDA- 2015/10/28 06:00
CRDT- 2015/05/20 06:00
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - 10.2169/internalmedicine.54.4329 [doi]
PST - ppublish
SO  - Intern Med. 2015;54(10):1219-22. doi: 10.2169/internalmedicine.54.4329. Epub 2015 
      May 15.