PMID- 25986741
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20161125
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 21
IP  - 7
DP  - 2015 Jul
TI  - Olfactory function combined with morphology distinguishes Parkinson's disease.
PG  - 771-7
LID - S1353-8020(15)00197-2 [pii]
LID - 10.1016/j.parkreldis.2015.05.001 [doi]
AB  - OBJECTIVE: This study aimed to examine whether the volume of the olfactory bulbs 
      and tracts (OB & T) on magnetic resonance imaging (MRI) is useful for 
      differentiating Parkinson's disease (PD) from PD-related disorders. METHODS: The 
      study group comprised 13 patients with PD, 11 with multiple system atrophy (MSA), 
      five with progressive supranuclear palsy, and five with corticobasal degeneration 
      (PSP/CBD). All patients were evaluated using the odor stick identification test 
      for Japanese (OSIT-J), (123)I-meta-iodobenzylguanidine (MIBG) scintigraphy, and 
      brain MRI. OB & T areas on 1-mm-thick coronal images were measured and summed for 
      volumes. We examined relationships between olfactory function and volume, and 
      cardiovascular dysautonomia. We defined the cut-off values for OSIT-J score or 
      MIBG uptake and OB & T volume to discriminate PD from PD-related disorders and 
      calculated the proportional rate of PD in four categorized groups. RESULTS: OB & 
      T volume was smaller in PD than in MSA or PSP/CBD (p < 0.05 each). The cut-off 
      for detecting PD patients was OSIT-J score <8, heart/mediastinum ratio <1.6, and 
      OB & T volume <270 mm(3). In the group with OSIT-J score <8 and OB & T volume 
      <270 mm(3), the proportion of PD patients among all patients with PD-related 
      disorders was 91%. The rate of probable PD gradually increased as OSIT-J score 
      and OB & T volume decreased (p < 0.001). CONCLUSIONS: Although preliminary, these 
      data obtained from a combined morphological and functional evaluation of OB or 
      cardiovascular dysautonomia could be useful for further differential of PD and 
      other PD-related disorders.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Sengoku, Renpei
AU  - Sengoku R
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan; 
      Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan. 
      Electronic address: renpeis@gmail.com.
FAU - Matsushima, Satoshi
AU  - Matsushima S
AD  - Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Bono, Keiko
AU  - Bono K
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Sakuta, Kenichi
AU  - Sakuta K
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Yamazaki, Mikihiro
AU  - Yamazaki M
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Miyagawa, Shinji
AU  - Miyagawa S
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Komatsu, Teppei
AU  - Komatsu T
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Mitsumura, Hidetaka
AU  - Mitsumura H
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Kono, Yu
AU  - Kono Y
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Kamiyama, Tsutomu
AU  - Kamiyama T
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Ito, Kimiteru
AU  - Ito K
AD  - Department of Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Mochio, Soichiro
AU  - Mochio S
AD  - The Jikei University School of Nursing, Tokyo, Japan.
FAU - Iguchi, Yasuyuki
AU  - Iguchi Y
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150511
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odorants
MH  - Olfaction Disorders/*diagnosis/physiopathology
MH  - Olfactory Bulb/*pathology/*physiology
MH  - Organ Size
MH  - Parkinson Disease/*diagnosis/physiopathology
OTO - NOTNLM
OT  - (123)I-MIBG scintigraphy
OT  - MRI
OT  - OB
OT  - OSIT-J
OT  - OT
OT  - Olfactory bulb and tract volume
OT  - Olfactory dysfunction
OT  - Parkinsonism
OT  - UPDRS
OT  - magnetic resonance imaging
OT  - meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy
OT  - meta-iodobenzylguanidine scintigraphy
OT  - odor stick identification test for Japanese
OT  - olfactory bulb
OT  - olfactory tract
OT  - unified Parkinson's Disease Rating Scale
EDAT- 2015/05/20 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/05/20 06:00
PHST- 2014/11/03 00:00 [received]
PHST- 2015/03/05 00:00 [revised]
PHST- 2015/05/02 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - S1353-8020(15)00197-2 [pii]
AID - 10.1016/j.parkreldis.2015.05.001 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2015 Jul;21(7):771-7. doi: 
      10.1016/j.parkreldis.2015.05.001. Epub 2015 May 11.