PMID- 25987216
OWN - NLM
STAT- MEDLINE
DCOM- 20160224
LR  - 20150519
IS  - 1095-9939 (Electronic)
IS  - 0048-3575 (Linking)
VI  - 120
DP  - 2015 May
TI  - Association of PCBs and allergies in children.
PG  - 21-6
LID - S0048-3575(14)00196-5 [pii]
LID - 10.1016/j.pestbp.2014.10.014 [doi]
AB  - Recently, the incidence rates of childhood allergies have been rising around the 
      world. The presence of persistent chemical pollutants in the environment and 
      exposure to air pollutants are often cited as potential causes of childhood 
      allergies. Accordingly, epidemiological studies of the associations between 
      exposure to low levels of pollutants and adverse health effects are essential. 
      However, at present no useful biomarkers for evaluating such associations have 
      been developed. Thus, using a molecular epidemiological approach we planned to 
      identify candidate biomarkers of pollutant-induced adverse health effects that 
      can be used in children. In asthmatic children, we found that the serum levels of 
      several polychlorinated biphenyl (PCB) congener sub-types were significantly 
      positively correlated with interleukin (IL)-8 mRNA expression, whereas in a 
      sub-group of children who displayed positive immunoglobulin E (IgE) responses to 
      milk or egg proteins IL-22 mRNA expression was demonstrated to be useful for 
      detecting the adverse health effects of environmental pollutants, particularly 
      PCB congeners. In conclusion, the mRNA expression levels of IL-8 and IL-22 can be 
      used to detect children who are at particular risk of adverse health events 
      caused by environmental pollutants, especially PCBs.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Tsuji, Mayumi
AU  - Tsuji M
AD  - Department of Environmental Toxicology, University of California, Davis, CA 
      95616, USA; Department of Environmental Health, University of Occupational and 
      Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu 807-8555, Japan. 
      Electronic address: tsuji@med.uoeh-u.ac.jp.
FAU - Kawamoto, Toshihiro
AU  - Kawamoto T
AD  - Department of Environmental Health, University of Occupational and Environmental 
      Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu 807-8555, Japan.
FAU - Koriyama, Chihaya
AU  - Koriyama C
AD  - Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate 
      School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, 
      Japan.
FAU - Yamamoto, Megumi
AU  - Yamamoto M
AD  - Integrated Physiology Section, Department of Basic Medical Science, National 
      Institute for Minamata Disease, 4058-18 Hama, Minamata, Kumamoto 867-0008, Japan.
FAU - Tsuchiya, Takuto
AU  - Tsuchiya T
AD  - Department of Environmental Health, University of Occupational and Environmental 
      Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu 807-8555, Japan.
FAU - Matsumura, Fumio
AU  - Matsumura F
AD  - Department of Environmental Toxicology, University of California, Davis, CA 
      95616, USA.
LA  - eng
PT  - Journal Article
DEP - 20141031
PL  - United States
TA  - Pestic Biochem Physiol
JT  - Pesticide biochemistry and physiology
JID - 1301573
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Egg Proteins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Milk Proteins)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Cytokines/genetics
MH  - Egg Proteins/immunology
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hypersensitivity/*blood/epidemiology/immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Infant
MH  - Japan/epidemiology
MH  - Milk Proteins/immunology
MH  - Polychlorinated Biphenyls/*blood
MH  - RNA, Messenger/metabolism
OTO - NOTNLM
OT  - Allergy
OT  - IL-22
OT  - IL-8
OT  - PCB
OT  - Young children
EDAT- 2015/05/20 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/05/20 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2014/10/21 00:00 [revised]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0048-3575(14)00196-5 [pii]
AID - 10.1016/j.pestbp.2014.10.014 [doi]
PST - ppublish
SO  - Pestic Biochem Physiol. 2015 May;120:21-6. doi: 10.1016/j.pestbp.2014.10.014. 
      Epub 2014 Oct 31.