PMID- 25987775 OWN - NLM STAT- MEDLINE DCOM- 20160411 LR - 20221207 IS - 2219-2840 (Electronic) IS - 1007-9327 (Print) IS - 1007-9327 (Linking) VI - 21 IP - 18 DP - 2015 May 14 TI - Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B. PG - 5524-31 LID - 10.3748/wjg.v21.i18.5524 [doi] AB - AIM: To compare the efficacy and safety of tenofovir disoproxil fumarate (TDF) in Asian and non-Asian chronic hepatitis B (CHB) patients. METHODS: The efficacy and safety of the initial 48 wk of treatment with TDF was compared in a post-hoc analysis of combined data from 217 Asians and 299 non-Asians included in Studies 102 and 103 and a post-approval, open-label trial (Study 123). Patient groups were compared according to baseline hepatitis B e antigen (HBeAg) status and viral load. The main outcome measures included the proportion of patients who achieved a hepatitis B virus (HBV) DNA level < 400 copies/mL at Week 48 of treatment. Secondary measures included: HBV DNA and alanine aminotransaminase (ALT) levels over time; proportion of patients with normal ALT levels; proportion of patients with HBeAg loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion; changes in liver histology. Safety and tolerability were evaluated by the occurrence of adverse events (AEs), serious AEs, laboratory abnormalities, discontinuation of the study drug due to AEs, or death. The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug. RESULTS: At week 48, similar proportions of Asians and non-Asians reached HBV DNA < 400 copies/mL (96% of Asian and 97% of non-Asian patients with HBeAg-negative CHB and 83% of Asian and 79% of non-Asian patients with HBeAg-positive CHB had HBV DNA) and normal ALT (78% of Asian and 81% of non-Asian patients with HBeAg-negative CHB and 71% of Asian and 74% of non-Asian patients with HBeAg-positive CHB had normal ALT). On-treatment HBV DNA decline rates were similar between Asians and non-Asians regardless of baseline HBeAg status and viral load. HBV DNA decline during the first four weeks was 2.9 log10 copies/mL in HBeAg-negative Asians and non-Asians, and in HBeAg-positive non-Asians, and 3.1 log10 copies/mL in HBeAg-positive Asians. HBeAg loss and seroconversion was achieved in 14% of Asians vs 26% and 24%, respectively, in non-Asians. Liver histology improved in 77.2% of Asians and 71.5% of non-Asians. No resistance to TDF developed. No renal safety signals were observed. CONCLUSION: TDF demonstrated similar viral suppression, normalization of ALT, improvements in liver fibrosis, and no detectable resistance in Asian and non-Asian patients regardless of baseline HBeAg status. FAU - Pan, Calvin Q AU - Pan CQ AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. FAU - Chan, Sing AU - Chan S AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. FAU - Trinh, Huy AU - Trinh H AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. FAU - Yao, Alan AU - Yao A AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. FAU - Bae, Ho AU - Bae H AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. FAU - Lou, Lillian AU - Lou L AD - Calvin Q Pan, Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York University School of Medicine, New York City, NY 11355, United States. LA - eng SI - ClinicalTrials.gov/NCT00116805 SI - ClinicalTrials.gov/NCT00117676 SI - ClinicalTrials.gov/NCT00736190 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - World J Gastroenterol JT - World journal of gastroenterology JID - 100883448 RN - 0 (Antiviral Agents) RN - 0 (Biomarkers) RN - 0 (Hepatitis B e Antigens) RN - 0 (RNA, Viral) RN - 99YXE507IL (Tenofovir) RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Adult MH - Alanine Transaminase/blood MH - Antiviral Agents/adverse effects/*therapeutic use MH - *Asian MH - Biomarkers/blood MH - Databases, Factual MH - Drug Resistance, Viral MH - Female MH - Hepatitis B e Antigens/blood MH - Hepatitis B virus/*drug effects/genetics/immunology MH - Hepatitis B, Chronic/diagnosis/*drug therapy/ethnology MH - Humans MH - Male MH - Middle Aged MH - RNA, Viral/blood MH - Randomized Controlled Trials as Topic MH - Tenofovir/adverse effects/*therapeutic use MH - Time Factors MH - Treatment Outcome MH - United States/epidemiology MH - Viral Load PMC - PMC4427674 OTO - NOTNLM OT - Asian patients OT - Chronic hepatitis B OT - Fibrosis OT - High viral load OT - Tenofovir EDAT- 2015/05/20 06:00 MHDA- 2016/04/12 06:00 PMCR- 2015/05/14 CRDT- 2015/05/20 06:00 PHST- 2014/08/07 00:00 [received] PHST- 2014/09/16 00:00 [revised] PHST- 2014/11/18 00:00 [accepted] PHST- 2015/05/20 06:00 [entrez] PHST- 2015/05/20 06:00 [pubmed] PHST- 2016/04/12 06:00 [medline] PHST- 2015/05/14 00:00 [pmc-release] AID - 10.3748/wjg.v21.i18.5524 [doi] PST - ppublish SO - World J Gastroenterol. 2015 May 14;21(18):5524-31. doi: 10.3748/wjg.v21.i18.5524.