PMID- 25987904
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150519
LR  - 20220408
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 7
DP  - 2015
TI  - Persistent organic pollutants as risk factors for type 2 diabetes.
PG  - 41
LID - 10.1186/s13098-015-0031-6 [doi]
LID - 41
AB  - Type 2 diabetes mellitus (T2DM) is a major and fast growing public health 
      problem. Although obesity is considered to be the main driver of the pandemic of 
      T2DM, a possible contribution of some environmental contaminants, of which 
      persistent organic pollutants (POPs) form a particular class, has been suggested. 
      POPs are organic compounds that are resistant to environmental degradation 
      through chemical, biological, and photolytic processes which enable them to 
      persist in the environment, to be capable of long-range transport, bio accumulate 
      in human and animal tissue, bio accumulate in food chains, and to have potential 
      significant impacts on human health and the environment. Several epidemiological 
      studies have reported an association between persistent organic pollutants and 
      diabetes risk. These findings have been replicated in experimental studies both 
      in human (in-vitro) and animals (in-vivo and in-vitro), and patho-physiological 
      derangements through which these pollutants exercise their harmful effect on 
      diabetes risk postulated. This review summarizes available studies, emphasises on 
      limitations so as to enable subsequent studies to be centralized on possible 
      pathways and bring out clearly the role of POPs on diabetes risk.
FAU - Ngwa, Elvis Ndonwi
AU  - Ngwa EN
AD  - Laboratory of Molecular Medicine and Metabolism, Biotechnology Centre Nkolbisson, 
      Biotechnology Centre Nkolbisson, Yaounde, Cameroon.
FAU - Kengne, Andre-Pascal
AU  - Kengne AP
AD  - Non-Communicable Diseases Research Unit, South African Medical Research Council, 
      Cape Town, South Africa ; Department of Medicine, University of Cape Town, Cape 
      Town, South Africa.
FAU - Tiedeu-Atogho, Barbara
AU  - Tiedeu-Atogho B
AD  - Laboratory of Molecular Medicine and Metabolism, Biotechnology Centre Nkolbisson, 
      Biotechnology Centre Nkolbisson, Yaounde, Cameroon.
FAU - Mofo-Mato, Edith-Pascale
AU  - Mofo-Mato EP
AD  - Laboratory of Molecular Medicine and Metabolism, Biotechnology Centre Nkolbisson, 
      Biotechnology Centre Nkolbisson, Yaounde, Cameroon.
FAU - Sobngwi, Eugene
AU  - Sobngwi E
AD  - Laboratory of Molecular Medicine and Metabolism, Biotechnology Centre Nkolbisson, 
      Biotechnology Centre Nkolbisson, Yaounde, Cameroon ; Department of Internal 
      Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University 
      of Yaounde 1, Yaounde, Cameroon ; National Obesity Center, Yaounde Central 
      Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaounde 
      1, P.O. Box 7535, Yaounde, Cameroon.
LA  - eng
PT  - Journal Article
DEP - 20150430
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4435855
OTO - NOTNLM
OT  - In utero exposure
OT  - Insulin resistance
OT  - Insulin secretion
OT  - Persistent organic pollutants
OT  - Type 2 diabetes
EDAT- 2015/05/20 06:00
MHDA- 2015/05/20 06:01
PMCR- 2015/04/30
CRDT- 2015/05/20 06:00
PHST- 2014/09/27 00:00 [received]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2015/05/20 06:01 [medline]
PHST- 2015/04/30 00:00 [pmc-release]
AID - 31 [pii]
AID - 10.1186/s13098-015-0031-6 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2015 Apr 30;7:41. doi: 10.1186/s13098-015-0031-6. 
      eCollection 2015.