PMID- 25988362
OWN - NLM
STAT- MEDLINE
DCOM- 20160325
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 May 19
TI  - Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal 
      neuroinflammation in rat model of monoarthritis.
PG  - 10278
LID - 10.1038/srep10278 [doi]
LID - 10278
AB  - Curcumin is a major component of turmeric and reportedly has anti-inflammatory 
      and anti-oxidant effects. Neuroinflammation has been recognized to play an 
      important role in the pathogenesis of various diseases in the central nervous 
      system. Here we investigated the anti-nociceptive and anti-neuroinflammatory 
      effect of curcumin on arthritic pain in rats. We found that repeated oral 
      treatment with curcumin, either before or after complete Freund's adjuvant (CFA) 
      injection, dose-dependently attenuated CFA-induced mechanical allodynia and 
      thermal hyperalgesia, but had no effect on joint edema. Repeated intrathecal 
      injection of curcumin reversed CFA-induced pain hypersensitivity. Furthermore, 
      such a curcumin treatment reduced CFA-induced activation of glial cells and 
      production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte 
      chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] 
      in the spinal cord. Curcumin also decreased lipopolysaccharide-induced production 
      of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and 
      microglia. Our results suggest that intrathecal curcumin attenuates arthritic 
      pain by inhibiting glial activation and the production of inflammatory mediators 
      in the spinal cord, suggesting a new application of curcumin for the treatment of 
      arthritic pain.
FAU - Chen, Jun-Jie
AU  - Chen JJ
AD  - 1] Department of Anesthesiology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, China [2] Pain Research Laboratory, Institute of 
      Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
FAU - Dai, Lin
AU  - Dai L
AD  - Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, China.
FAU - Zhao, Lin-Xia
AU  - Zhao LX
AD  - Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, 
      Nantong, Jiangsu 226019, China.
FAU - Zhu, Xiang
AU  - Zhu X
AD  - Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, China.
FAU - Cao, Su
AU  - Cao S
AD  - Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, China.
FAU - Gao, Yong-Jing
AU  - Gao YJ
AD  - Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, 
      Nantong, Jiangsu 226019, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150519
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (IL1B protein, rat)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antioxidants/therapeutic use
MH  - Arthritis, Experimental/chemically induced/*drug therapy
MH  - Astrocytes/drug effects/pathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/biosynthesis
MH  - Chemokine CCL3/biosynthesis
MH  - Curcumin/administration & dosage/*therapeutic use
MH  - Hyperalgesia/*drug therapy
MH  - Inflammation/drug therapy/immunology
MH  - Injections, Spinal
MH  - Interleukin-1beta/biosynthesis
MH  - Lipopolysaccharides
MH  - Male
MH  - Microglia/drug effects/pathology
MH  - Pain/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/drug effects/metabolism
MH  - Spine/pathology
PMC - PMC4437313
EDAT- 2015/05/20 06:00
MHDA- 2016/03/26 06:00
PMCR- 2015/05/19
CRDT- 2015/05/20 06:00
PHST- 2015/01/23 00:00 [received]
PHST- 2015/04/08 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2016/03/26 06:00 [medline]
PHST- 2015/05/19 00:00 [pmc-release]
AID - srep10278 [pii]
AID - 10.1038/srep10278 [doi]
PST - epublish
SO  - Sci Rep. 2015 May 19;5:10278. doi: 10.1038/srep10278.