PMID- 25988526
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20220410
IS  - 1533-2500 (Electronic)
IS  - 1530-7085 (Linking)
VI  - 16
IP  - 5
DP  - 2016 Jun
TI  - Hyperbaric Oxygen Therapy: A New Treatment for Chronic Pain?
PG  - 620-8
LID - 10.1111/papr.12312 [doi]
AB  - BACKGROUND AND OBJECTIVE: Hyperbaric oxygen therapy (HBOT) is a treatment 
      providing 100% oxygen at a pressure greater than that at sea level. HBOT is 
      becoming increasingly recognized as a potential treatment modality for a broad 
      range of ailments, including chronic pain. In this narrative review, we discuss 
      the current understanding of pathophysiology of nociceptive, inflammatory and 
      neuropathic pain, and the body of animal studies addressing mechanisms by which 
      HBOT may ameliorate these different types of pain. Finally, we review clinical 
      studies suggesting that HBOT may be useful in treating chronic pain syndromes, 
      including chronic headache, fibromyalgia, complex regional pain syndrome, and 
      trigeminal neuralgia. DATABASE AND DATA TREATMENT: A comprehensive search through 
      MEDLINE, EMBASE, Scopus, and Web of Science for studies relating to HBOT and pain 
      was performed using the following keywords: hyperbaric oxygen therapy or 
      hyperbaric oxygen treatment (HBOT), nociceptive pain, inflammatory pain, 
      neuropathic pain, HBOT AND pain, HBOT AND headache, HBOT AND fibromyalgia, HBOT 
      AND complex regional pain syndrome, and HBOT AND trigeminal neuralgia. RESULTS: 
      Twenty-five studies examining the role of HBOT in animal models of pain and human 
      clinical trials were found and reviewed for this narrative review. CONCLUSIONS: 
      HBOT has been shown to reduce pain using animal models. Early clinical research 
      indicates HBOT may also be useful in modulating human pain; however, further 
      studies are required to determine whether HBOT is a safe and efficacious 
      treatment modality for chronic pain conditions.
CI  - (c) 2015 World Institute of Pain.
FAU - Sutherland, Ainsley M
AU  - Sutherland AM
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, 
      University Health Network, Toronto, ON, Canada.
FAU - Clarke, Hance A
AU  - Clarke HA
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, 
      University Health Network, Toronto, ON, Canada.
FAU - Katz, Joel
AU  - Katz J
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, 
      University Health Network, Toronto, ON, Canada.
AD  - Department of Psychology, York University, Toronto, ON, Canada.
FAU - Katznelson, Rita
AU  - Katznelson R
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, 
      University Health Network, Toronto, ON, Canada.
AD  - Hyperbaric Medical Unit, Department of Anesthesia and Pain Management, Toronto 
      General Hospital, Toronto, ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20150519
PL  - United States
TA  - Pain Pract
JT  - Pain practice : the official journal of World Institute of Pain
JID - 101130835
SB  - IM
MH  - Animals
MH  - Chronic Pain/*therapy
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Models, Animal
OTO - NOTNLM
OT  - analgesia
OT  - animal models
OT  - cluster headache
OT  - complex regional pain syndromes
OT  - fibromyalgia
OT  - hyperbaric oxygen therapy
OT  - inflammation
OT  - neuropathic pain
OT  - nociception
OT  - review
OT  - trigeminal neuralgia
EDAT- 2015/05/20 06:00
MHDA- 2017/02/10 06:00
CRDT- 2015/05/20 06:00
PHST- 2015/02/04 00:00 [received]
PHST- 2015/03/27 00:00 [accepted]
PHST- 2015/05/20 06:00 [entrez]
PHST- 2015/05/20 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
AID - 10.1111/papr.12312 [doi]
PST - ppublish
SO  - Pain Pract. 2016 Jun;16(5):620-8. doi: 10.1111/papr.12312. Epub 2015 May 19.