PMID- 25989653
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 29
IP  - 2
DP  - 2015 Jan
TI  - [Expression of CDK4 and p16 in laryngeal squamous cell carcinoma].
PG  - 108-10
AB  - OBJECTIVE: To investigate the expression of CDK4 and p16 in laryngeal squamous 
      cell carcinoma (LSCC) tissues. METHOD: The expressions of CDK4 and p16 in 30 
      cases of LSCC tissues and 20 cases of edge tissues were detected by 
      immunohistochemical technology SP method, and discuss their correlation with 
      clincial pathology and clinical stage of LSCC. RESULT: The positive rates of CDK4 
      and p16 were 63. 3 %,46. 7% in LSCC tissues, and the positive rates were 25%, 90% 
      in edge tissues. The expression of CDK4 in LSCC tissues was significantly higher 
      than that in edge tissues(P<0. 05), which was not associated with the clincial 
      pathology and clinical stage(P> 0. 05); The expression of p16 in LSCC tissues was 
      significantly lower than that in edge tissues(P<0. 05), it was associated with 
      the clincial pathology (P<0. 05), but not associated with clinical stage(P>0. 05) 
      ;there is a negative correlation between CDK4 and p16 (r= -0. 786, P<0. 05). 
      CONCLUSION: Low expression of p16 and high expression of CDK4 may play an 
      important role in the development of LSCC and the low expression of p16 in LSCC 
      tissue could be used as important reference markers of malignant degree of 
      tumour.
FAU - Zhang, Junxing
AU  - Zhang J
FAU - Geng, Manying
AU  - Geng M
FAU - Su, Lei
AU  - Su L
FAU - Zhang, Hui
AU  - Zhang H
FAU - Lu, Xing
AU  - Lu X
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cyclin-Dependent Kinase 4/*biosynthesis
MH  - Cyclin-Dependent Kinase Inhibitor p16/*biosynthesis
MH  - Head and Neck Neoplasms/*metabolism
MH  - Laryngeal Neoplasms/*metabolism
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2015/05/21 06:00
MHDA- 2015/06/03 06:00
CRDT- 2015/05/21 06:00
PHST- 2015/05/21 06:00 [entrez]
PHST- 2015/05/21 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jan;29(2):108-10.