PMID- 25989836
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20161230
IS  - 1475-2697 (Electronic)
IS  - 0022-149X (Linking)
VI  - 90
IP  - 3
DP  - 2016 May
TI  - Immune responses in children infected with the pinworm Enterobius vermicularis in 
      central Greece.
PG  - 337-41
LID - 10.1017/S0022149X15000334 [doi]
AB  - Previous studies have suggested an immunomodulatory and even protective role for 
      Enterobius vermicularis, the least pathogenic human intestinal helminth. Here, in 
      a study using haematological and serological parameters, we tested a total of 215 
      children from central Greece, with a mean age of 8.39, of whom 105 (48.84%) were 
      infected with E. vermicularis and 110 (51.16%) were matched healthy controls. In 
      particular, we analysed eosinophil counts (EO), serum eosinophil cationic protein 
      (ECP), total and specific serum immunoglobulin E (IgE) and the ECP/EO ratio. The 
      atopic status and the potential occurrence of clinically expressed allergic 
      diseases were both taken into account. Eosinophils, ECP and IgE were found to be 
      higher in infected than in uninfected children, indicating a type-2 immune 
      response activation during infection. Atopic infected children exhibited higher 
      IgE levels compared to non-atopic ones. EO and ECP were found to be lower in 
      atopic children who had a history of allergic disease than in those with no such 
      history. The type-2 oriented immune response elicited against E. vermicularis 
      could contribute to a balanced activation of the immune system in the examined 
      children. Interestingly, although the atopic children showed a stronger 
      activation, they did not exhibit any symptoms and, moreover, there seemed to be 
      some indication of immunosuppression in those children with a positive history of 
      allergic disease.
FAU - Patsantara, G G
AU  - Patsantara GG
AD  - Platia Xenia,32004Arachova,Greece.
FAU - Piperaki, E-T
AU  - Piperaki ET
AD  - Department of Microbiology, Medical School,National and Kapodistrian University 
      of Athens,Mikras Asias St. 75,11527Athens,Greece.
FAU - Tzoumaka-Bakoula, C
AU  - Tzoumaka-Bakoula C
AD  - A. Papanastasiou St. 35, P. Psychiko,15452Athens,Greece.
FAU - Kanariou, M G
AU  - Kanariou MG
AD  - Department of Immunology-Histocompatibility 'Aghia Sophia' Children's 
      Hospital,Thivon & Papadiamantopoulou,11527Athens,Greece.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150520
PL  - England
TA  - J Helminthol
JT  - Journal of helminthology
JID - 2985115R
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Enterobiasis/*immunology
MH  - Enterobius/*immunology/isolation & purification
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Leukocyte Count
MH  - Male
EDAT- 2015/05/21 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/05/21 06:00
PHST- 2015/05/21 06:00 [entrez]
PHST- 2015/05/21 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0022149X15000334 [pii]
AID - 10.1017/S0022149X15000334 [doi]
PST - ppublish
SO  - J Helminthol. 2016 May;90(3):337-41. doi: 10.1017/S0022149X15000334. Epub 2015 
      May 20.