PMID- 25990566
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20220318
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 113
IP  - 12
DP  - 2015 Jun 28
TI  - Cytokine and growth factor profiling in patients with the metabolic syndrome.
PG  - 1911-9
LID - 10.1017/S0007114515001038 [doi]
AB  - The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that 
      may partially account for its association with an increased cardiovascular risk. 
      We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth 
      factors (epidermal growth factor (EGF), interferon-gamma (IFN-gamma), 
      IL-1alpha/-1beta/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha and 
      vascular endothelial growth factor (VEGF)) in 303 individuals with or without the 
      MetS; and (2) explore their relationship with the presence of the MetS. Patients 
      with the MetS had significantly higher serum concentrations of IFN-gamma, EGF, 
      IL-1alpha/-1beta/-2/-4/-6/-8/-10, MCP-1 and TNF-alpha, whilst serum VEGF concentrations were 
      markedly lower compared with the control group (e.g. 38.55 v. 82.18 pg/ml; 
      P< 0.05). Amongst these parameters, IFN-gamma and IL-1alpha emerged as the most 
      significant independent predictors of the MetS. In conclusion, our findings 
      demonstrate that patients with the MetS had an altered blood cytokine and growth 
      factor profile that may partially account for its adverse clinical outcomes. 
      Further prospective studies in larger multi-centre settings are required to 
      unravel the role and association of the emerging biomarkers with the MetS and 
      their implication in therapeutic intervention.
FAU - Mirhafez, Seyed Reza
AU  - Mirhafez SR
AD  - Department of Basic Medical Sciences,Neyshabur University of Medical 
      Sciences,Neyshabur,Iran.
FAU - Pasdar, Alireza
AU  - Pasdar A
AD  - Department of New Science and Technologies,School of Medicine, Mashhad University 
      of Medical Sciences,Mashhad,Iran.
FAU - Avan, Amir
AU  - Avan A
AD  - Department of New Science and Technologies,School of Medicine, Mashhad University 
      of Medical Sciences,Mashhad,Iran.
FAU - Esmaily, Habibollah
AU  - Esmaily H
AD  - Department of Biostatistics and Epidemiology,School of Medicine, Mashhad 
      University of Medical Sciences,Mashhad,Iran.
FAU - Moezzi, Atefeh
AU  - Moezzi A
AD  - Cardiovascular Research Center, School of Medicine, Mashhad University of Medical 
      Sciences,Mashhad,Iran.
FAU - Mohebati, Mohsen
AU  - Mohebati M
AD  - Cardiovascular Research Center, School of Medicine, Mashhad University of Medical 
      Sciences,Mashhad,Iran.
FAU - Meshkat, Zahra
AU  - Meshkat Z
AD  - Department of New Science and Technologies,School of Medicine, Mashhad University 
      of Medical Sciences,Mashhad,Iran.
FAU - Mehrad-Majd, Hassan
AU  - Mehrad-Majd H
AD  - Department of Basic Medical Sciences,Neyshabur University of Medical 
      Sciences,Neyshabur,Iran.
FAU - Eslami, Saied
AU  - Eslami S
AD  - Department of Medical Informatics,School of Medicine, Mashhad University of 
      Medical Sciences,Mashhad,Iran.
FAU - Rahimi, Hamid Reza
AU  - Rahimi HR
AD  - Department of New Science and Technologies,School of Medicine, Mashhad University 
      of Medical Sciences,Mashhad,Iran.
FAU - Ghazavi, Hamed
AU  - Ghazavi H
AD  - Department of Medical Biotechnology,School of Medicine, Mashhad University of 
      Medical Sciences,Mashhad,Iran.
FAU - Ferns, Gordon A
AU  - Ferns GA
AD  - Division of Medical Education, Brighton & Sussex Medical School, Falmer,Brighton, 
      SussexBN1 9PH,UK.
FAU - Ghayour-Mobarhan, Majid
AU  - Ghayour-Mobarhan M
AD  - Department of New Science and Technologies,School of Medicine, Mashhad University 
      of Medical Sciences,Mashhad,Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150520
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Interleukins)
RN  - 0 (Triglycerides)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Chemokine CCL2/blood
MH  - Cholesterol, HDL/blood
MH  - Cytokines/*blood
MH  - Epidermal Growth Factor/blood
MH  - Fasting
MH  - Female
MH  - Growth Substances/*blood
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-1alpha/blood
MH  - Interleukins/blood
MH  - Male
MH  - Metabolic Syndrome/*blood/complications
MH  - Middle Aged
MH  - Obesity, Abdominal/blood/complications
MH  - Triglycerides/blood
MH  - Vascular Endothelial Growth Factor A/blood
MH  - Waist Circumference
OTO - NOTNLM
OT  - Cytokines
OT  - Diabetes
OT  - Growth factors
OT  - Inflammation
OT  - Metabolic syndrome
EDAT- 2015/05/21 06:00
MHDA- 2015/09/22 06:00
CRDT- 2015/05/21 06:00
PHST- 2015/05/21 06:00 [entrez]
PHST- 2015/05/21 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - S0007114515001038 [pii]
AID - 10.1017/S0007114515001038 [doi]
PST - ppublish
SO  - Br J Nutr. 2015 Jun 28;113(12):1911-9. doi: 10.1017/S0007114515001038. Epub 2015 
      May 20.