PMID- 25992864
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20181113
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 42
IP  - 5
DP  - 2015 May 19
TI  - Epidermal Fatty Acid binding protein promotes skin inflammation induced by 
      high-fat diet.
PG  - 953-964
LID - 10.1016/j.immuni.2015.04.016 [doi]
AB  - Defining specific cellular and molecular mechanisms in most obesity-related 
      diseases remains an important challenge. Here we report a serendipitous finding 
      that consumption of a high-fat diet (HFD) greatly increased the occurrence of 
      skin lesions in C57BL/6 mice. We demonstrated that HFD induced the accumulation 
      of a specific type of CD11c(+) macrophages in skin preceding detectable lesions. 
      These cells primed skin to induce IL-1beta and IL-18 signaling, which further 
      promoted the cytokines IFN-gamma- and IL-17-mediated skin inflammation. 
      Mechanistically, epidermal fatty acid binding protein (E-FABP) was significantly 
      upregulated in skin of obese mice, which coupled lipid droplet formation and 
      NLRP3 inflammasome activation. Deficiency of E-FABP in obese mice decreased 
      recruitment of CD11c(+) macrophages in skin tissues, reduced production of IL-1beta 
      and IL-18, and consequently dampened activation of effector T cells. Furthermore, 
      E-FABP-deficient mice are completely resistant to HFD-induced skin lesions. 
      Collectively, E-FABP represents a molecular sensor triggering HFD-induced skin 
      inflammation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Zhang, Yuwen
AU  - Zhang Y
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
FAU - Li, Qiang
AU  - Li Q
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
AD  - Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated 
      to Shandong University, Jinan, Shandong, 250021, China.
FAU - Rao, Enyu
AU  - Rao E
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
FAU - Sun, Yanwen
AU  - Sun Y
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
AD  - Mayo Clinic Health System, Austin, MN, 55912, USA.
FAU - Grossmann, Michael E
AU  - Grossmann ME
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
FAU - Morris, Rebecca J
AU  - Morris RJ
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
FAU - Cleary, Margot P
AU  - Cleary MP
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
FAU - Li, Bing
AU  - Li B
AD  - The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
LA  - eng
GR  - UL1TR000135/TR/NCATS NIH HHS/United States
GR  - CA18098601A1/CA/NCI NIH HHS/United States
GR  - CA157012/CA/NCI NIH HHS/United States
GR  - P30 DK050456/DK/NIDDK NIH HHS/United States
GR  - 5P30DK50456/DK/NIDDK NIH HHS/United States
GR  - U24 DK100469/DK/NIDDK NIH HHS/United States
GR  - R01 CA157012/CA/NCI NIH HHS/United States
GR  - R01 CA177679/CA/NCI NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
GR  - CA17767901A1/CA/NCI NIH HHS/United States
GR  - U24DK100469/DK/NIDDK NIH HHS/United States
GR  - R01 CA180986/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
RN  - 0 (Fabp5 protein, mouse)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Fatty Acid-Binding Proteins/deficiency/genetics/immunology/*metabolism
MH  - Immunohistochemistry
MH  - Inflammation/*etiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neoplasm Proteins/deficiency/genetics/immunology/*metabolism
MH  - Skin Diseases/genetics/*immunology
MH  - T-Lymphocytes/immunology
PMC - PMC4440244
MID - NIHMS687054
EDAT- 2015/05/21 06:00
MHDA- 2015/08/01 06:00
PMCR- 2016/05/19
CRDT- 2015/05/21 06:00
PHST- 2014/06/11 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/03/15 00:00 [accepted]
PHST- 2015/05/21 06:00 [entrez]
PHST- 2015/05/21 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
PHST- 2016/05/19 00:00 [pmc-release]
AID - 10.1016/j.immuni.2015.04.016 [doi]
PST - ppublish
SO  - Immunity. 2015 May 19;42(5):953-964. doi: 10.1016/j.immuni.2015.04.016.